DEFB104A, defensin beta 104A, 140596

N. diseases: 43; N. variants: 0
Disease: Psoriasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 AlteredExpression disease BEFREE Four genes (IL22RA1, KRT17, DEFB4 and TSLP), known to be upregulated in psoriatic lesions, and thereby key players in psoriasis pathogenesis were selected. 28833576 2018
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 Biomarker disease BEFREE We explored the potential benefits of targeting hBD-2 by topical application of DEFB4-siRNA-containing SECosomes in a bioengineered skin-humanized mouse model for psoriasis. 24428418 2014
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 Biomarker disease BEFREE Increased DEFB4 copy number is a susceptibility factor for psoriasis, whereas a single study in a Crohn's disease (CD) cohort reported that decreased DEFB4 copy number is associated with colonic inflammation. 19809410 2010