CSF2, colony stimulating factor 2, 1437

N. diseases: 1028; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE <i>In vitro</i> stimulation of macrophages isolated from tumor tissue of colorectal cancer with granulocyte macrophage colony-stimulating factor and lipopolysaccharide did not drive to an inflammatory phenotype. 29456737 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE Interleukin-34 (IL-34), a cytokine produced by a wide range of cells, binds to the macrophage colony-stimulating factor receptor (M-CSFR-1) and receptor-type protein-tyrosine phosphatase zeta (PTP-z) and controls myeloid cell differentiation, proliferation and survival. various types of cancers over-express IL-34 but the role of the cytokine in colorectal cancer (CRC) remains unknown. 29423057 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE Overall, these findings shed new insights into the mechanisms of GM-CSF underlying CAC development, by inducing/recruiting CAC-promoting MDSCs. 28534709 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE In the present study, the therapeutic efficacy of oncolytic herpes simplex virus type 2 (oHSV2) in CRC was assessed in vitro and in vivo. oHSV2 is an oncolytic agent derived from herpes simplex virus type 2 that encodes granulocyte-macrophage colony-stimulating factor. 28223815 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE GM-CSF but not M-CSF-stimulated macrophages significantly (P < 0.02) inhibited colorectal cancer cell proliferation. 24737547 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE Patients, disease-free after CRC metastasectomy and perioperative chemotherapy (n = 74), were randomized to injections of autologous DCs modified with PANVAC (DC/PANVAC) or PANVAC with per injection GM-CSF (granulocyte-macrophage colony-stimulating factor). 23657083 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Therapeutic disease CTD_human In an effort to improve the therapeutic effect of a MAb-based regimen in colorectal carcinoma (CRC) patients, the effects of a combination of alpha-interferon (alpha-IFN), 5-fluorouracil (5-FU), granulocyte-macrophage colony-stimulating factor (GM-CSF) and mouse MAb17-1A was evaluated in 27 patients with metastatic disease. alpha-IFN was given s.c. once daily for 5 consecutive days and at days 4 and 5, 5-FU was administered as a daily i.v. bolus injection. 15289873 2004
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE Immunization of colorectal carcinoma patients with a recombinant canarypox virus expressing the tumor antigen Ep-CAM/KSA (ALVAC-KSA) and granulocyte macrophage colony- stimulating factor induced a tumor-specific cellular immune response. 12855617 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.380 Biomarker disease BEFREE Colorectal cancers are known to be infiltrated by dendritic cells (DC) and neoplastic cells have been shown to produce GM-CSF. 10738251 2000