CST3, cystatin C, 1471

N. diseases: 370; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Biomarker disease BEFREE Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice. 30504006 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Biomarker disease BEFREE In contrast, cystatin C was shown to be a protective factor against progression to dementia. 29357793 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Biomarker disease BEFREE Three hypotheses were tested: (1) higher levels of high-sensitivity cardiac troponin T, N-terminal of prohormone brain natriuretic peptide, and cystatin C predict risk of death, cardiovascular disease, HF, and dementia; (2) higher levels of cardiovascular disease biomarkers are associated with increased risk of HF and then secondary increased risk of dementia; and (3) risk of dementia is lower among participants with a combination of lower coronary artery calcium, atherosclerosis, and lower high-sensitivity cardiac troponin T (myocardial injury). 28735291 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 AlteredExpression disease BEFREE We conclude that, in Lewy body disease, the CST3 BB genotype and low CSF CysC levels are associated with dementia, possibly through a disturbed elimination of soluble Abeta(42). 20157249 2010
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Therapeutic disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Therapeutic disease CTD_human Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. 18026100 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Biomarker disease CTD_human Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. 18026100 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Biomarker disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.350 Biomarker disease BEFREE Up to now, amyloid-beta (A beta), cystatin C, and prion proteins have been known to be deposited as amyloid in the brain, leading to stroke or dementia. 8579098 1996