CST3, cystatin C, 1471

N. diseases: 370; N. variants: 10
Disease: Alzheimer Disease, Late Onset ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease BEFREE Although flanking SNP cover the whole gene transcript with strong linkage disequilibrium, our data show that the CST3 gene is not associated with AD risk in the Finnish population. 19293566 2009
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease BEFREE Some reports claim that cystatin C binds soluble Abeta, making transgenic animals healthier, others, in contrast, that deleting cystatins genes may contribute to amyloid pathology in animal models of AD. 19382231 2009
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease CTD_human Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. 18026100 2007
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Therapeutic disease CTD_human Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. 18026100 2007
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Therapeutic disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 Biomarker disease BEFREE Genotype and plasma concentration of cystatin C in patients with late-onset Alzheimer disease. 17310123 2007
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE Genetic association of the cystatin C gene with late-onset Alzheimer disease.Arch.Neurol.57, 1579-1583). 16213753 2006
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE The association of a cystatin C gene polymorphism with late-onset Alzheimer's disease and vascular dementia. 14672279 2003
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease. 10993992 2000
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.370 GeneticVariation disease BEFREE Homozygosity for haplotype B of CST3 was significantly associated with late-onset AD in both study populations, with an odds ratio of 3.8 (95% confidence interval, 1.56-9.25) in the combined data set; heterozygosity was not associated with an increased risk. 11074789 2000