ADRA1A, adrenoceptor alpha 1A, 148

N. diseases: 294; N. variants: 30
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group BEFREE G<sub>s</sub>-coupled GPCR signalling is regulated by G protein-coupled receptor kinases (GRK) and arrestin proteins, and dysregulation of Gs/GPCR signalling is thought play a role in the development of hypertension, which may be a consequence of enhanced GRK2 and/or arrestin expression. 30075183 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 AlteredExpression group BEFREE G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart - a response to pathological cues including hypertension and myocardial infarction. 28412414 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 GeneticVariation group BEFREE Some studies have found a positive correlation between the Arg347Cys polymorphism of the α1a-adrenergic receptor to hypertension and heart autonomic control. 24548768 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group BEFREE These include the contribution of variants of the regulator of G protein signaling (RGS) protein to hypertension; the role variants of the activator of G protein signaling (AGS) proteins to phenotypes (such as the type III AGS8 variant to hypoxia); the contribution of G protein-coupled receptor kinase (GRK) proteins, such as GRK4, in disorders such as hypertension. 25150869 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group LHGDN Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension. 19011682 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 GeneticVariation group BEFREE In the case of the G protein-coupled receptor kinases (GRKs), identified originally in the retinal tissues that converge on rhodopsin, proteins such as GRK4 have been identified that have been subsequently associated with hypertension. 18370232 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group BEFREE In addition, an 'uncoupling' of the G-protein-coupled receptor/G-protein complex is the principal mechanism underlying impaired G-protein-coupled-receptor-mediated vasodilatation in hypertension. 16481879 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 GeneticVariation group LHGDN Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension. 16685204 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 GeneticVariation group BEFREE In Japanese patients with newly diagnosed, untreated hypertension (n = 184), we studied polymorphisms in 10 genes, including G protein-coupled receptor kinase type 4 (GRK4), some variations of which are associated with hypertension and impair D1 receptor (D1R)-inhibited renal sodium transport. 16439609 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group RGD Captopril therapy decreases both expression and function of alpha-adrenoceptors in pre- hypertensive rat aorta. 16371063 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group BEFREE G-protein-coupled receptor kinases (GRKs) are implicated in the pathophysiology of human diseases such as arterial hypertension, heart failure and rheumatoid arthritis. 15225142 2004