Congestive heart failure
|
0.500 |
Biomarker
|
disease |
BEFREE |
CCN2/connective tissue growth factor (CTGF), a CCN family matricellular protein repressed in healthy hearts after birth, is induced in heart failure of various etiologies.
|
21186275 |
2011 |
Congestive heart failure
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure.
|
23582094 |
2013 |
Congestive heart failure
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Subsequent gene/ncRNA expression analysis was assessed using quantitative reverse transcription polymerase chain reaction and revealed 6 genes: 4 hypermethylated ( HEY2, MSR1, MYOM3, and COX17), 2 hypomethylated ( CTGF and MMP2); and 2 microRNA: 1 hypermethylated (miR-24-1), 1 hypomethylated (miR-155) with significantly upregulated or downregulated expression levels consistent with the direction of methylation in the particular HF subgroup.
|
30798618 |
2019 |
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-8 and CTGF are essential for the pathogenesis of CHF.
|
30898581 |
2019 |
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
BEFREE |
Myocardial connective tissue growth factor (CTGF/CCN2) is induced in heart failure, a condition associated with diminution of β-adrenergic receptor (β-AR) responsiveness.
|
23778361 |
2013 |
Congestive heart failure
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure.
|
21501375 |
2011 |
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
BEFREE |
CTGF related heart failure was associated with Akt and JNK activation, but not with the induction of natriuretic peptides.
|
19707545 |
2009 |
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
BEFREE |
Key steps where CCNs may play a pathogenic metabolic role include: (i) obesity and insulin resistance, where CCN2 inhibits fat cell differentiation in vitro and CCN3 may induce obesity and insulin resistance; (ii) elevated blood glucose levels to diabetes mellitus onset, where CCN2 may contribute to pancreatic beta cell and islet function; and (iii) in diabetes complications, such as nephropathy, retinopathy, liver disease (NAFLD/NASH), CVD and diabetes with heart failure.
|
29411334 |
2018 |
Congestive heart failure
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A promoter polymorphism -945C>G in the connective tissue growth factor in heart failure patients with mechanical circulatory support: a new marker for bridge to recovery?
|
25349161 |
2015 |
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
CTD_human |
The aim of this study was to observe changes in CTGF expression in cardiomyocyte of young rats with HF and effect of benazepril on CTGF.
|
17229371 |
2006 |
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
BEFREE |
HSPG and CTGF were diffusely abundant in fibrous portal tracts/septa in CHF, while they were more or less accentuated at periportal areas in alcoholic F/C and CVH.
|
15998433 |
2005 |
Congestive heart failure
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of TGF‑β and CTGF were decreased, whereas those of miR‑29b, miR‑30c and miR‑133a were increased, in the HF + RSD group compared with the HF + sham group.
|
28849013 |
2017 |
Congestive heart failure
|
0.500 |
Biomarker
|
disease |
BEFREE |
Myocardial CCN2/CTGF is induced in heart failure of various etiologies.
|
23284892 |
2012 |