Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Subsequently, to determine the role of Galectin‑1 in liver fibrosis, the expression levels of transforming growth factor (TGF)‑β1, connective tissue growth factor (CTGF) and α‑smooth muscle actin (α‑SMA) pre‑ and post‑transfection were evaluated by reverse transcription‑quantitative polymerase chain reaction and western blot analyses. 30365068 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE In this study, we confirmed that the expression of CTGF/CCN2 was increased in BDL-induced rodent cholestatic liver fibrosis. 30384360 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Hepatic Smurf2 overexpression also inhibited the production of connective tissue growth factor (CTGF), a central mediator of liver fibrosis. 29100790 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE With the severity of liver fibrosis, the expression of TGF-β, α-SMA, Smad3 and CTGF gradually increased, and the difference was statistically significant (p < 0.01). 29330836 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Intact Nlrp3<sup>A350V</sup> mutants showed changes in liver fibrosis, as evidenced by morphometric quantitation of Sirius Red staining and increased mRNA levels of profibrotic genes, including connective tissue growth factor and tissue inhibitor of matrix metalloproteinase 1. 28902427 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Furthermore, the study suggests that blocking of MMP-13 and CTGF has potential therapeutic implications to arrest liver fibrosis. 28782260 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Connective tissue growth factor (CTGF) plays a crucial role in the pathogenesis of hepatic fibrosis and emerges as downstream of the profibrogenic cytokine transforming growth factor-β (TGF-β). 28798388 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Experimental cholestatic liver fibrosis was associated with induced gene expression of fibrotic markers such as collagen I, fibronectin, alpha smooth muscle actin (SMA), and connective tissue growth factor (CTGF); increased inflammatory cytokines (TNF<i>α</i>, MIP1<i>α</i>, IL1<i>β</i>, and MIP2); increased oxidative stress and reactive oxygen species- (ROS-) inducing enzymes (NOX2 and iNOS); dysfunctional mitochondrial electron chain complexes; and apoptotic/necrotic cell death markers (DNA fragmentation, caspase 3 activity, and PARP activity). 28757911 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Pathways of liver fibrosis are controlled by connective tissue growth factor (CCN2). 27662798 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Collectively, these results provide evidence for the fibrotic role of LPCs in the liver and suggest that the Activin A-Smad-CTGF/CCN2 signaling in LPCs may be a therapeutic target of liver fibrosis. 27011166 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE The gradual increase of CTGF and TGF-β1 expression levels in liver tissue is associated with liver fibrosis. 26909983 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis. 25111595 2015
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Finally, the levels of Twist1, miR-214, or CCN2 in circulating exosomes from fibrotic mice reflected fibrosis-induced changes in the liver itself, highlighting the potential utility of these and other constituents in serum exosomes as novel circulating biomarkers for liver fibrosis. 26229009 2015
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE We advocate combined elimination of TGF-β signaling and connective tissue growth factor as a potential therapeutic target by which to attenuate liver fibrosis. 25108224 2014
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Silencing CTGF expression with siRNA prevented liver fibrosis in CCl4-induced rat model. 23456538 2014
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Taken together, our results provide evidence for the role of HPCs in liver fibrosis and suggest that the production of CTGF by TGF-β activated MAPK signaling in HPCs may be a therapeutic target of liver fibrosis. 23727026 2013
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 GeneticVariation disease BEFREE Two groups of CCN2 polymorphisms independently modulate the progression of hepatic fibrosis. 23414795 2013
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE After intravenous injection, CSLN/siCTGF complex was target specifically delivered to the liver and resulted in a significant reduction in collagen content and pro-fibrogenic factors like tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), interleukin-6 (IL-6), and CTGF with the dramatic improvement of patho-physiological symptoms in liver fibrosis model rats. 23092863 2013
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Detection of serum CCN2 in patients with CLD-B may have clinical significance for assessment of severity of hepatic fibrosis. 22611323 2012
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Whereas hepatic levels of CTGF/CCN2 are usually low, elevated levels of hepatic CTGF/CCN2 occur in patients with liver fibrosis and in experimental animal models of liver fibrosis. 22652794 2012
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE CTGF was linked to the histological degree of liver fibrosis. 19243500 2009
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Liver fibrosis can be induced by environmental chemicals or toxicants, and finally stimulates fibrogenic cytokines expression, such as transforming growth factor-beta (TGF-beta) and its downstream mediator connective tissue growth factor (CTGF). 19429239 2009
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 GeneticVariation disease BEFREE We show that the single nucleotide polymorphism (SNP) rs9402373 that lies close to CTGF is associated with severe HF (P = 2 x 10(-6); odds ratio [OR] = 2.01; confidence interval of OR [CI] = 1.51-2.7) in two Chinese samples, in Sudanese, and in Brazilians infected with either Schistosoma japonicum or S. mansoni. 19822645 2009
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease CTD_human Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. 17657819 2007