Mental Depression
|
0.530 |
Biomarker
|
disease |
PSYGENET |
The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo.
|
21859713 |
2011 |
Mental Depression
|
0.530 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we have characterized the direct interaction between DMI and the α(2A)-adrenergic receptor (α(2A)AR), a key regulator of noradrenergic neurotransmission with altered expression and function in depression.
|
21859713 |
2011 |
Mental Depression
|
0.530 |
Biomarker
|
disease |
RGD |
Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism.
|
20047711 |
2010 |
Mental Depression
|
0.530 |
Biomarker
|
disease |
PSYGENET |
Our findings suggest that ADRA2A plays an important role in depression therapy.
|
18794646 |
2008 |
Mental Depression
|
0.530 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that ADRA2A plays an important role in depression therapy.
|
18794646 |
2008 |
Mental Depression
|
0.530 |
GeneticVariation
|
disease |
BEFREE |
The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers.
|
16333651 |
2006 |
Mental Depression
|
0.530 |
Biomarker
|
disease |
PSYGENET |
The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers.
|
16333651 |
2006 |
Mental Depression
|
0.530 |
Biomarker
|
disease |
PSYGENET |
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
|
11425914 |
2001 |
Hypertensive disease
|
0.520 |
Biomarker
|
group |
RGD |
Adrenal α2-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat.
|
20691504 |
2012 |
Hypertensive disease
|
0.520 |
GeneticVariation
|
group |
BEFREE |
Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks.
|
16636200 |
2006 |
Hypertensive disease
|
0.520 |
GeneticVariation
|
group |
LHGDN |
Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks.
|
16636200 |
2006 |
Hypertensive disease
|
0.520 |
Biomarker
|
group |
CTD_human |
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol.
|
10694191 |
2000 |
Hypertensive disease
|
0.520 |
GeneticVariation
|
group |
BEFREE |
The alpha(2A)-adrenoceptor polymorphism was not significantly associated with blood pressure or a family history of hypertension.
|
10534508 |
1999 |
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Two hundred and thirty-seven clozapine-treated Finnish schizophrenia patients were genotyped for CHRM1, CHRM3, CLOCK and ADRA2A polymorphisms, and their salivary dysfunction was assessed with two questions.
|
25163438 |
2014 |
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment.
|
25163438 |
2014 |
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152).
|
22940547 |
2013 |
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152).
|
22940547 |
2013 |
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Our result suggests that the ADRA2A C-1291G polymorphism may not confer susceptibility to polydipsia in schizophrenia in our sample.
|
19439247 |
2009 |
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Our result suggests that the ADRA2A C-1291G polymorphism may not confer susceptibility to polydipsia in schizophrenia in our sample.
|
19439247 |
2009 |
Schizophrenia
|
0.340 |
Biomarker
|
disease |
PSYGENET |
With attention directed at the upstream regulatory region of the gene which codes for this receptor (ADRA2A), we proposed that single nucleotide polymorphisms (SNPs) within this region influences susceptibility to schizophrenia by altering the expression of this receptor.
|
17034020 |
2007 |
Schizophrenia
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
With attention directed at the upstream regulatory region of the gene which codes for this receptor (ADRA2A), we proposed that single nucleotide polymorphisms (SNPs) within this region influences susceptibility to schizophrenia by altering the expression of this receptor.
|
17034020 |
2007 |
Depressive disorder
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we have characterized the direct interaction between DMI and the α(2A)-adrenergic receptor (α(2A)AR), a key regulator of noradrenergic neurotransmission with altered expression and function in depression.
|
21859713 |
2011 |
Depressive disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
The antidepressant desipramine is an arrestin-biased ligand at the α(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo.
|
21859713 |
2011 |
Depressive disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Our findings suggest that ADRA2A plays an important role in depression therapy.
|
18794646 |
2008 |
Depressive disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that ADRA2A plays an important role in depression therapy.
|
18794646 |
2008 |