Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Autoantibodies to beta-1 adrenergic receptor have been reported in adult patients with dilated cardiomyopathy (DCM).
|
30468641 |
2019 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
BEFREE |
To introduce an animal model, we investigated the β1-AAB associated autoimmunity in Doberman Pinscher (DP) with dilated cardiomyopathy, which has similarities to human DCM.
|
31276517 |
2019 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Myocarditis/dilated cardiomyopathy (DCM) patients can develop autoantibodies to various cardiac antigens and one major antigen is β1-adrenergic receptor (β<sub>1</sub>AR).
|
29209317 |
2017 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, this meta-analysis suggests that no statistically increased risk was found between β1-adrenergic receptor gene polymorphisms and susceptibility to IDCM among Europeans.
|
21553224 |
2012 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, a previously used ELISA conducted with a linear 26-meric peptide derived from the second extracellular β1-AR loop yielded a high number of false-positive results precluding any specific identification of DCM patients.
|
22811559 |
2012 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
BEFREE |
An autoantibody targeting the β1-adrenergic receptor is related to the persistent myocardial damage resulting in DCM and provides the substrate for fatal ventricular arrhythmias.
|
21617318 |
2011 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Dobutamine stress testing is a useful diagnostic tool for identifying reduced adrenergic myocardial contractile reserve related to altered myocardial expression of beta(1)-adrenergic receptor, sarcoplasmic reticulum Ca(2+)-adenosine triphosphatase, and phospholamban genes even in asymptomatic or mildly symptomatic patients with DCM.
|
19356507 |
2008 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have explored the effects of beta(1)AR autoantibodies obtained from DCM patients on extracellular signal-regulated kinase (ERK) activation in murine cardiomyocytes.
|
17628514 |
2007 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Evidence confirms that autoantibodies that bind to M(2) muscarinic (M(2)AChR) and beta(1) adrenergic receptors (beta(1)AR) are present in idiopathic dilated cardiomyopathy and Chagasic patients' sera.
|
15850564 |
2005 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In vitro, the Gly389 variant of beta1-AR mediates less adenylyl cyclase activities than the Arg389 variant, so Arg389Gly polymorphism was investigated with regard to the genesis, progression, or arrhythmogenesis of dilated cardiomyopathy (DCM).
|
12197595 |
2002 |
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
CTD_human |
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
|
9554809 |
1998 |