|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Endothelial function and atherosclerosis were examined by nitric oxide-related-products (NOx: NO2- and NO3-), O2-, endothelial NO synthase (eNOS), NADPH oxidase (p22phox), and ICAM1.
|
31266015 |
2019 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In healthy premenopausal women, the CYBA C242T polymorphism is an independent determinant of endothelial function and subclinical atherosclerosis of the carotid arteries.
|
29948131 |
2018 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CYBA C242T polymorphism has been associated with cardiovascular phenotypes such as hypertension and atherosclerosis, but available data are conflicting.
|
22268370 |
2012 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to analyze potential interactions between CYBA gene A640G polymorphism and traditional risk factors of atherosclerosis.
|
21777168 |
2011 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The A640G CYBA polymorphism may be a marker of oxidative stress risk and may be indicative of subclinical atherosclerosis in type 2 diabetes.
|
21622150 |
2011 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas.
|
20720404 |
2010 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we enrolled 1746 type 2 diabetic subjects, determined 4 common genetic variants related to oxidative stress (glutamate-cysteine ligase modifier subunit (GCLM) C-588T, myeloperoxidase G-463A, human paraoxonase 1 Gln192Arg and NAD(P)H oxidase p22phox C242T polymorphisms), and measured carotid intima-media thickness (IMT) as a surrogate marker for atherosclerosis.
|
19126404 |
2009 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.
|
18158642 |
2008 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Relationship between coronary plaque formation and NAD(P)H oxidase-derived reactive oxygen species - comparison of intravascular ultrasound finding of atherosclerotic lesions with histochemical characteristics-.
|
17684442 |
2007 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some studies have identified a relationship between progression of atherosclerosis and C242T mutation in CYBA gene coding for p22phox, a subunit of the NADH/NADPH oxidase system.
|
16788250 |
2006 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some studies have identified reduced atherosclerosis in the presence of the C242T CYBA polymorphism, whereas others have not.
|
15078863 |
2004 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
These results show that the C242T mutation in the p22 phox gene is associated with progression of asymptomatic atherosclerosis in the subjects with type 2 diabetes and is also associated with insulin resistance in nondiabetic subjects.
|
12547880 |
2003 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results show that the C242T mutation in the p22 phox gene is associated with progression of asymptomatic atherosclerosis in the subjects with type 2 diabetes and is also associated with insulin resistance in nondiabetic subjects.
|
12547880 |
2003 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of p22phox, an essential component of the NADPH oxidase system, are found to be associated with atherosclerosis, while a recent study found a significant association between the 214C>T polymorphism and the occurrence of ischemic cerebrovascular disease.
|
13130177 |
2003 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of gp91phox and p22phox mRNA was associated with the severity of atherosclerosis. gp91phox correlated with the plaque macrophage content, whereas Nox4 correlated with the content of alpha-actin-positive cells.
|
11914250 |
2002 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Carriers of the CC genotype of the C242T p22 phox polymorphism (n = 44) revealed a significantly blunted endothelium-dependent dilator response (11 +/- 9.2% luminal area change vs 17 +/- 10%;P = 0.007), which was, by multivariate analysis, independent of other risk factors or atherosclerosis itself.
|
11133215 |
2001 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the CYBA 242T allele with reduced NAD(P)H oxidase activity in human blood vessels suggests that genetic variation in NAD(P)H oxidase components may play a significant role in modulating superoxide production in human atherosclerosis.
|
11023926 |
2000 |