|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The NAPDH oxidase (Nox) family is emerging as a key disease-related factor in vascular diseases, but currently its role in hypoxia-induced pulmonary remodelling in COPD remains unclear.Here we investigate the role of p22phox, a regulatory subunit of Nox, in COPD lungs, hypoxic pulmonary vasoconstriction (HPV), hypoxia-induced pulmonary vascular remodelling and pulmonary hypertension.In COPD, compared to control lungs, p22phox expression was significantly reduced.
|
28729471 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The CYBA Gene (⁎)49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease.
|
27314008 |
2016 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
CYBA (p22(phox)) variants influence the markers of oxidative stress and are associated with hypertension.
|
25787042 |
2015 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Blood pressure or the prevalence of hypertension did not vary between C242T p22PHOX genotypes or in the presence or absence of the T-allele.
|
24573492 |
2014 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
According to the results of cross-sectional study, the tested polymorphism of the NADPH oxidase P22phox gene (rs4673) was found to be associated with the development of AH, indicating that the oxidative stress gene NADPH oxidase might be implicated in the pathogenesis of AH in subjects with type 2 diabetes.
|
23701472 |
2014 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The A930G polymorphism ofP22phox (CYBA) gene but not C242T variation is associated with hypertension: a meta-analysis.
|
24349292 |
2013 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Reactive oxygen species are implicated in the physiopathogenesis of salt-induced hypertension and the C242T polymorphism of the p22-phox gene has been associated with higher superoxide production.
|
24339896 |
2013 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
These data suggest that the T allele of the CYBA C242T polymorphism may be used as a marker for adverse metabolic features in Brazilian subjects with systemic hypertension.
|
22268370 |
2012 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
|
20018820 |
2010 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In L-NAME treated rats, relative to Ad.Null or saline administration, Ad.CMV-hAM-4F2 (i) reduced augmented cardiomyocyte membrane protein oxidation and mRNA expression of pro-oxidant (p22phox) and anti-oxidant (SOD-3, GPx) genes; (ii) attenuated increased cardiomyocyte width and mRNA expression of hypertrophic (sk-alpha-actin) and cardio-endocrine (ANP) genes; (iii) did not attenuate hypertension.
|
20798523 |
2010 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
The effect of p22(phox) -930A/G, A640G and C242T polymorphisms of NADPH oxidase on peripheral and central pressures in healthy, normotensive individuals.
|
20505675 |
2010 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension.
|
19516159 |
2009 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The -930A/G polymorphism of the CYBA gene (that codes p22phox, a major component of the NADPH oxidase) has been associated with human hypertension and with a reduction in NADPH oxidase activity.
|
19043982 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells.
|
18158642 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD(P)H oxidase-mediated oxidative stress and hypertension.
|
17314996 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (or P22PHOX) (16q24), NOX1 (10q22), and NOX3 (6q25.1-q26).
|
17336700 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney.
|
17324946 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (or P22PHOX) (16q24), NOX1 (10q22), and NOX3 (6q25.1-q26).
|
17336700 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension.
|
17620958 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The C242T polymorphism was not in linkage disequilibrium with the -930A/G CYBA promoter variation, which also associates with hypertension.
|
16794479 |
2006 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Serum thiobarbituric acid reactive substances concentration and aortic superoxide anion concentration were estimated to assess oxidative stress.8-Br-cAMP (5 mg/kg, i.p.) or atorvastatin (30 mg/kg, p.o.) prevented hypertension-induced attenuation of acetylcholine-induced endothelium-dependent relaxation, impairment of vascular endothelial lining, decrease in expression of mRNA for endothelial nitric oxide synthase (eNOS), serum nitrite/nitrate concentration and increase in expression of mRNA for p22phox, superoxide anion and serum TBARS.
|
17109653 |
2006 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension.
|
16115038 |
2006 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats: effects of angiotensin II blockade.
|
16685210 |
2006 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Logistic analysis indicated that the CYBA/G(-930)A polymorphism was associated with hypertension in male subjects.
|
15671602 |
2005 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in the p22phox gene promoter could determine susceptibility to NAD(P)H-mediated oxidative stress in humans and animals with hypertension.
|
16026320 |
2005 |