GRK2, G protein-coupled receptor kinase 2, 156

N. diseases: 159; N. variants: 2
Disease: Rheumatoid Arthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.340 Biomarker disease BEFREE Our results demonstrate that CP-25 has therapeutic potential for the treatment of human RA via GRK2 regulation. 30643209 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.340 AlteredExpression disease BEFREE Whether GRK2 mediated-EP4 over-desensitization reduces the level of cAMP and inhibits M2 polarization in RA is unclear. 31818003 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.340 AlteredExpression disease BEFREE However, the imbalance of GRK2 expression and activity plays an important role in the development of IIR-related diseases, such as hypertension, heart failure, Alzheimer's disease, type 2 diabetes mellitus, insulin resistance, rheumatoid arthritis, thyroid cancer, multiple sclerosis, and liver cancer. 30463058 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.340 AlteredExpression disease BEFREE We found a significant decrease in GRK activity in RA subjects that is mirrored by a decrease in GRK-2 protein expression. 10094932 1999
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.340 Biomarker disease CTD_human Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. 10094932 1999