Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the effectiveness of CYP2D6 pharmacogenetic screening to accelerate drug dosing in older patients with depression initiating nortriptyline or venlafaxine.
|
31688392 |
2020 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
182 subjects diagnosed with depression and treated with these drugs were clinically and therapeutically characterized and submitted to the quantification of drug/metabolite plasma concentrations and genotyping of ABCB1, CYP2C9, CYP2C19, and CYP2D6 genes.
|
31120287 |
2020 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Effects of CYP2D6 activity on the efficacy and safety of mirtazapine in patients with depressive disorders and comorbid alcohol use disorder.
|
31100205 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The predictors of delayed remission included unemployment (P = .004), severe medical comorbidity (P < .0001), severe baseline depression (P < .0001), more than 4 dysthymic symptoms (P = .005), more than 9 posttraumatic stress symptoms (P = .005), and serotonin receptor 1A (P = .006) and cytochrome P450 2D6 (P = .002 for C/T and P = .0004 for T/T) genetic variants.
|
29178685 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Specifically, the potential of the CYP2D6 to be inhibited by drug-induced phenoconversion was associated with a higher severity of depression (<i>p</i> < .05).
|
31750687 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The activity of brain and liver cytochrome P450 2D (CYP2D) is differently affected by antidepressants in the chronic mild stress (CMS) model of depression in the rat.
|
30195732 |
2018 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effects of CYP2D6 genetic polymorphisms on the efficacy and safety of fluvoxamine in patients with depressive disorder and comorbid alcohol use disorder.
|
29988737 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Herein, we present the case of a 29-year-old male with diagnoses of depression and obsessive compulsive disorder who had trialed and failed a dozen psychiatric medications, many of which are subject to metabolism by CYP2D6 and/or CYP2C19, and had most recently been taking clomipramine for approximately 2.5 years.
|
28470111 |
2017 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of our study was to determine the frequency of CYP2D6 allelic variants and the prevalence of predicted CYP2D6 phenotypes in patients who were suffering from difficult-to-treat depression and compare the data with those for the healthy population of Hungary.55 patients who failed to respond to 2 or more adequate trials of different CYP2D6-dependent antidepressants were selected for genotyping.The prevalence of the predicted CYP2D6 phenotypes in the patient population was 1.8% for the UMs, 80.0% for EMs, 3.6% for IMs and 14.5% for PMs compared with 1.9% for UMs, 83.3% for EMs, 6.5% for IMs and 8.3% for PMs in the Hungarian population.The CYP2D6 allele frequencies and the predicted phenotype distributions in patients with difficult-to-treat depression were not significantly different to those found in the healthy population of Hungary.
|
23737191 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cytochrome P450 2D6 phenoconversion is common in patients being treated for depression: implications for personalized medicine.
|
23541126 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The aim of our study was to determine the frequency of CYP2D6 allelic variants and the prevalence of predicted CYP2D6 phenotypes in patients who were suffering from difficult-to-treat depression and compare the data with those for the healthy population of Hungary.55 patients who failed to respond to 2 or more adequate trials of different CYP2D6-dependent antidepressants were selected for genotyping.The prevalence of the predicted CYP2D6 phenotypes in the patient population was 1.8% for the UMs, 80.0% for EMs, 3.6% for IMs and 14.5% for PMs compared with 1.9% for UMs, 83.3% for EMs, 6.5% for IMs and 8.3% for PMs in the Hungarian population.The CYP2D6 allele frequencies and the predicted phenotype distributions in patients with difficult-to-treat depression were not significantly different to those found in the healthy population of Hungary.
|
23737191 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Cytochrome P450 2D6 phenoconversion is common in patients being treated for depression: implications for personalized medicine.
|
23541126 |
2013 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A medical history of depression and/or use of antidepressants was reported in 37% (10/27) of these breast cancer patients genotyped for CYP2D6*4.
|
22638694 |
2012 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Extended CYP2D6 genotyping was subsequently performed in an implementation data set of 27 Caucasian breast cancer patients, to determine the prevalence of depression and use of antidepressants in a clinical setting.
|
22638694 |
2012 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report the effect of CYP2C19 and CYP2D6 genotypes on steady state morning concentrations of escitalopram and N-desmethylescitalopram and the ratio of this metabolite to the parent drug in 196 adult patients with depression in GENDEP, a clinical pharmacogenomic trial.
|
21926427 |
2012 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We report the effect of CYP2C19 and CYP2D6 genotypes on steady state morning concentrations of escitalopram and N-desmethylescitalopram and the ratio of this metabolite to the parent drug in 196 adult patients with depression in GENDEP, a clinical pharmacogenomic trial.
|
21926427 |
2012 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Sequenced Treatment Alternatives to Relieve Depression sample was used to examine the relationship between variations in the CYP2C19 and CYP2D6 genes and remission of depressive symptoms and tolerance to treatment with citalopram.
|
21192344 |
2011 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The Sequenced Treatment Alternatives to Relieve Depression sample was used to examine the relationship between variations in the CYP2C19 and CYP2D6 genes and remission of depressive symptoms and tolerance to treatment with citalopram.
|
21192344 |
2011 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Neither did we find an association between CYP2D6 genotype and minor depression (OR = 1.56; 95% CI: 0.69-3.52; p = 0.28).
|
19374513 |
2009 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression.
|
11682257 |
2001 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic tests suitable for the routine laboratory are now available for some important metabolizing enzymes (e.g., CYP2D6, CYP2C19) identifying those individuals who are slow or fast metabolizers of certain drugs, many of which are widely used in the treatment of depression (e.g., tricyclic antidepressants).
|
11412815 |
2001 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The clinical relevance of the CYP2D6 oxidation polymorphism in the treatment of depression with desipramine (DMI) was studied prospectively in depressed outpatients.
|
9049581 |
1997 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the extent and time course of CYP2D6 inhibition in patients, six males (mean age: 40 years, range: 29-64 years), who were starting treatment for depression with sertraline, were phenotyped on five occasions (once before treatment and approximately 3, 7, 14, and 21 days later).
|
10950472 |
1997 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CYP2D6 genotype was assessed in 74 outpatients who had received diagnoses of depression.
|
8941025 |
1996 |