|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hairy Calycosin can effectively control the lipid peroxidation in liver tissues of rats with NAFLD, and reduce the levels of serum TNF-α, IL-6, MDA and FFA, effectively improve the steatosis and inflammation of liver tissue, and down-regulate the expression of CYP2E1, inhibit apoptosis of hepatocytes.
|
30973105 |
2019 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, irrespective of CYP2E1 overexpression; EtOH dose and hepatic ADH deficiency contribute to EtOH-induced steatosis and liver injury, suggesting a linkage between ER stress, dysregulated hepatic lipid metabolism and AMPK signaling.
|
31581705 |
2019 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
|
28987868 |
2018 |
|
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis.
|
27349771 |
2017 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that the TSG-rich fraction (TSGP) significantly lowered the serum total cholesterol and triglyceride levels, and the liver free fatty acid, CYP2E1 mRNA and malondialdehyde levels, in addition to mitigating hepatic enlargement and alleviating liver steatosis.
|
29201200 |
2017 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CXCL10 was linked to steatosis through upregulation of the lipogenic factors SREBP-1c and LXR, and also to oxidative stress (upregulation of CYP2E1 and C/EBPβ).
|
25048951 |
2014 |
|
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury.
|
25462060 |
2014 |
|
Steatohepatitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that CYP2E1 Pst I/Rsa I polymorphism might be not significantly associated with advanced form of ALD (ALC), but might be significantly associated with other form of ALD such as steatosis, hepatisis, fibrosis.
|
23335995 |
2013 |
|
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is the absence of CYP2E1 in the KO mice that is responsible for the blunting of steatosis and oxidant stress because restoring the CYP2E1 restores the fatty liver and oxidant stress.
|
20692331 |
2010 |
|
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice.
|
18952117 |
2009 |
|
Steatohepatitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Chlorzoxazone hydroxylase activity showed significant enhancement in the steatohepatitis group (15%, p=0.027) compared with the normal group. c2 rare allele of RsallPstl polymorphisms but no C allele of Dral polymorphism was positively associated with CHZ hydroxylation, which in turn is correlated with liver CYP2E1 content (r=0.59; p=0.026).
|
18769766 |
2008 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For patients suspected to have NASH, noninvasive tests including the determination of the CYP2E1 activity are unable to distinguish them from patients with steatosis.
|
17617119 |
2007 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that increased hepatocyte CYP2E1 expression and the presence of steatohepatitis result in the down-regulation of insulin signaling, potentially contributing to the insulin resistance associated with nonalcoholic fatty liver disease.
|
15632182 |
2005 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both oral and intragastric low-carbohydrate ethanol diets resulted in marked steatosis with additional inflammation and necrosis accompanied by significantly increased serum ALT, high levels of CYP2E1 expression, and production of auto-antibodies against malondialdehyde and hydroxyethyl free radical protein adducts.
|
15044719 |
2004 |
|
Steatohepatitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic polymorphism of CYPIIE1 on the position of Pst I and Rsa I is related to the susceptibility of fatty liver.
|
14606109 |
2003 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I, tumor necrosis factor-alpha and cytochrome P450 2E1.
|
12653886 |
2003 |
|
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunoglobulin G (IgG) recognizing human CYP2E1 and HER-derived epitopes were measured by microplate immunosorbent assay in the sera of 90 patients with alcoholic fibrosis/cirrhosis (ALD), 37 heavy drinkers without liver disease or steatosis only (HD), and 59 healthy subjects.
|
12540792 |
2003 |