Hepatoma, Morris
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Expression profiling and identification of novel genes in hepatocellular carcinomas.
|
11420682 |
2001 |
Hepatoma, Novikoff
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Expression profiling and identification of novel genes in hepatocellular carcinomas.
|
11420682 |
2001 |
Liver Neoplasms, Experimental
|
0.200 |
Biomarker
|
phenotype |
CTD_mouse |
Expression profiling and identification of novel genes in hepatocellular carcinomas.
|
11420682 |
2001 |
Experimental Hepatoma
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Expression profiling and identification of novel genes in hepatocellular carcinomas.
|
11420682 |
2001 |
Malignant neoplasm of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans.
|
29496518 |
2018 |
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans.
|
29496518 |
2018 |
Primary malignant neoplasm of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans.
|
29496518 |
2018 |
Malignant neoplasm of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer.
|
17327131 |
2007 |
Malignant neoplasm of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity.
|
17943660 |
2007 |
Carcinoma of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity.
|
17943660 |
2007 |
Carcinoma of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer.
|
17327131 |
2007 |
Primary malignant neoplasm of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer.
|
17327131 |
2007 |
Primary malignant neoplasm of lung
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity.
|
17943660 |
2007 |
Lung Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The limited response of 4HS in KO and TG mice may result from intrinsic toxicity or from further metabolism; regardless of the MOA, these findings indicate that the CYP2F-mediated tumorigenic MOA in WT mice is not operative for S, SO, or for 4HS putatively derived from metabolism of S by CYP2F1 in humans, and thus S-induced mouse lung tumors are unlikely to be relevant to human risk.
|
23454103 |
2013 |
Lung Neoplasms
|
0.020 |
GeneticVariation
|
group |
LHGDN |
Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant.
|
17327131 |
2007 |
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans.
|
29496518 |
2018 |
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans.
|
29496518 |
2018 |
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Since human cytochrome P450 2F1 (CYP2F1) is predominantly expressed in lung tissue and is involved in the metabolism of various pneumotoxicants with potential carcinogenic effects, variations in the nucleotidic sequence of its gene may contribute to interindividual and interethnic differences in the susceptibility to lung tumorigenesis.
|
17943660 |
2007 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
P450 expression was also detected in lymph node metastasis and the presence of several P450s (CYP1B1, CYP2A/2B, CYP2F1, CYP4V2, and CYP39) in the lymph node metastasis strongly correlated with their presence in corresponding primary tumors.
|
15897573 |
2005 |
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
P450 expression was also detected in lymph node metastasis and the presence of several P450s (CYP1B1, CYP2A/2B, CYP2F1, CYP4V2, and CYP39) in the lymph node metastasis strongly correlated with their presence in corresponding primary tumors.
|
15897573 |
2005 |