Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019207
Disease: Hepatoma, Morris
Hepatoma, Morris
0.200 Biomarker disease CTD_mouse Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C0019208
Disease: Hepatoma, Novikoff
Hepatoma, Novikoff
0.200 Biomarker disease CTD_mouse Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental
0.200 Biomarker phenotype CTD_mouse Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C0086404
Disease: Experimental Hepatoma
Experimental Hepatoma
0.200 Biomarker disease CTD_mouse Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.030 AlteredExpression disease BEFREE Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans. 29496518 2018
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.030 AlteredExpression disease BEFREE Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans. 29496518 2018
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.030 AlteredExpression disease BEFREE Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans. 29496518 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.030 GeneticVariation disease BEFREE However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer. 17327131 2007
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.030 GeneticVariation disease BEFREE These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity. 17943660 2007
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.030 GeneticVariation disease BEFREE These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity. 17943660 2007
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.030 GeneticVariation disease BEFREE However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer. 17327131 2007
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.030 GeneticVariation disease BEFREE However, our preliminary results did not show any evidence that the CYP2F1 genetic polymorphism has implications in the pathogenesis of lung cancer. 17327131 2007
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.030 GeneticVariation disease BEFREE These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity. 17943660 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.020 Biomarker group BEFREE The limited response of 4HS in KO and TG mice may result from intrinsic toxicity or from further metabolism; regardless of the MOA, these findings indicate that the CYP2F-mediated tumorigenic MOA in WT mice is not operative for S, SO, or for 4HS putatively derived from metabolism of S by CYP2F1 in humans, and thus S-induced mouse lung tumors are unlikely to be relevant to human risk. 23454103 2013
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.020 GeneticVariation group LHGDN Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant. 17327131 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 AlteredExpression group BEFREE Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans. 29496518 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 AlteredExpression group BEFREE Based on complete attenuation of styrene short-term and chronic toxicity in CYP2F2 knockout mice and similar attenuation in CYP2F1 (humanized) transgenic mice, limited metabolism of styrene in human lung by CYP2F1, 2 + orders of magnitude lower SO levels in human lung compared to mouse lung, and lack of styrene-related increase in lung cancer in humans, styrene does not present a risk of cancer to humans. 29496518 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 GeneticVariation phenotype BEFREE Since human cytochrome P450 2F1 (CYP2F1) is predominantly expressed in lung tissue and is involved in the metabolism of various pneumotoxicants with potential carcinogenic effects, variations in the nucleotidic sequence of its gene may contribute to interindividual and interethnic differences in the susceptibility to lung tumorigenesis. 17943660 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 Biomarker group BEFREE P450 expression was also detected in lymph node metastasis and the presence of several P450s (CYP1B1, CYP2A/2B, CYP2F1, CYP4V2, and CYP39) in the lymph node metastasis strongly correlated with their presence in corresponding primary tumors. 15897573 2005
Secondary malignant neoplasm of lymph node
0.010 Biomarker disease BEFREE P450 expression was also detected in lymph node metastasis and the presence of several P450s (CYP1B1, CYP2A/2B, CYP2F1, CYP4V2, and CYP39) in the lymph node metastasis strongly correlated with their presence in corresponding primary tumors. 15897573 2005