Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.020 Biomarker group BEFREE The limited response of 4HS in KO and TG mice may result from intrinsic toxicity or from further metabolism; regardless of the MOA, these findings indicate that the CYP2F-mediated tumorigenic MOA in WT mice is not operative for S, SO, or for 4HS putatively derived from metabolism of S by CYP2F1 in humans, and thus S-induced mouse lung tumors are unlikely to be relevant to human risk. 23454103 2013
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.020 GeneticVariation group LHGDN Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant. 17327131 2007