|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SNPs rs72553867 (IRGM gene), rs4409764 (NKX2-3 gene), and rs3731772 (AOX1 gene) increase the risk of pCD.
|
31844038 |
2019 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15.
|
25489960 |
2015 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls.
|
24473197 |
2014 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls.
|
24473197 |
2014 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found 14 SNPs tagging 9 loci, including 21q21.1, NKX2-3, MST1, the HLA region, 1p36.13, IL10, JAK2, ORMDL3, and IL23R, to be associated with UC.
|
23974994 |
2013 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both CD and UC patients.
|
22377701 |
2012 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1.
|
21968973 |
2012 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1.
|
21968973 |
2012 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both CD and UC patients.
|
22377701 |
2012 |
|
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found strong evidence of CD-association for 195 genes, identifying novel susceptibility genes (e.g., ISX, SLCO6A1, TMEM183A) as well as confirming many previously identified susceptibility genes in CD GWAS (e.g., IL23R, NOD2, CYLD, NKX2-3, IL12RB2, ATG16L1).
|
23071489 |
2012 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC.
|
21514341 |
2011 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consistent with epidemiologic predictions, many IBD-associated loci demonstrate genome-wide significant associations to both CD and UC, notably, genes whose products function in the interleukin-23 pathway, and transcription factors, including NK2 transcription factor related, locus 3 (NKX2-3), SMAD3, STAT3, ZMIZ1, and c-REL.
|
21530736 |
2011 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A correlation with NKX2-3 and need for surgery (P = 0.038), and with HLA and steroid-responsiveness (P = 0.024) in UC patients was observed.
|
21818367 |
2011 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the pediatric cohort the associations of TNFSF15, NKX2-3 with CD, and PTGER4, NKX2-3, ZNF365, IFNG, PSMG1 with UC, were confirmed.
|
21818367 |
2011 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC.
|
21514341 |
2011 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79).
|
21049557 |
2010 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nkx2-3 gene variants are strongly associated with inflammatory bowel disease (IBD) and its expression is up-regulated in Crohn's disease (CD).
|
20188614 |
2010 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79).
|
21049557 |
2010 |
|
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nkx2-3 has been reported to be up-regulated in B cell lines and intestinal tissues from Crohn's disease patients and down-regulated in colorectal cancer.
|
20165982 |
2010 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
An association between NKX2-3 and UC susceptibility was replicated and diverse evidence of epistasis in Japan was suggested.
|
19340882 |
2009 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.
|
18936107 |
2009 |
|
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, no evidence of association with CD has been reported for the Crohn's disease susceptibility polymorphisms studied in the NKX2-3, ATG16L1, and IRGM genes.
|
19683022 |
2009 |