DCC, DCC netrin 1 receptor, 1630

N. diseases: 279; N. variants: 101
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker disease BEFREE CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in Stage II-III MSS colon cancer. 28006840 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker disease BEFREE Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. 18054557 2007
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker disease BEFREE According to Fearon and Vogelstein model, further somatic mutations in the K-ras oncogene, DCC gene and p53 tumor suppressor gene are prerequisite for development of colon carcinoma. 11263856 2000
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 GeneticVariation disease BEFREE The deleted in colorectal cancer (DCC) gene was initially described as a colon cancer-associated tumor suppressor gene and subsequently proposed to be involved in goblet cell differentiation, but its precise role in normal intestine physiology and in cancer remains to be established. 10328236 1999
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 AlteredExpression disease BEFREE Quantitation of DCC protein expression in tissue specimens by densitometry demonstrated that both normal and malignant specimens exhibit a wide range of DCC protein levels and there was no significant correlation between diminished DCC protein expression and colon cancer progression. 8761300 1996
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 Biomarker disease BEFREE In order to clarify the association between bcl-2 protein (Bcl-2) expression and genetic alteration, we investigated p53 and DCC (deleted in the colon carcinoma gene locus) gene abnormalities in Bcl-2-positive and -negative gastric carcinomas using a polymerase chain reaction/loss of heterozygosity (LOH) assay. 8690754 1996
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 GeneticVariation disease BEFREE Human colon cancer development is associated with the accumulation of mutations and deletions in the suppressor genes DCC, APC and p53 and mutations in the dominant oncogene K-ras, with loss of wild type alleles. 7970729 1994
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 AlteredExpression disease BEFREE Lack of correlation between the gap junctional communication capacity of human colon cancer cell lines and expression of the DCC gene, a homologue of a cell adhesion molecule (N-CAM). 8396566 1993
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.090 GeneticVariation disease BEFREE Because both ovarian and colon cancer are features of Lynch syndrome II, which has been provisionally mapped to chromosome 18, we hypothesized that loss of heterozygosity at the DCC locus may also occur in ovarian neoplasia. 1594239 1992