Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Rate of Cough During Treatment With Angiotensin-Converting Enzyme Inhibitors: A Meta-Analysis of Randomized Placebo-Controlled Trials.
|
29330882 |
2019 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Demographic and Clinical Characteristics of Patients Presenting With Angiotensin-converting Enzyme Inhibitors Induced Cough.
|
31700727 |
2019 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This study demonstrated that ACE I/D but not BDKRB2-58T/C polymorphism could be a predictor for the risk of ACE inhibitor-induced cough, especially in east Asians and the aged.
|
30672376 |
2019 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Cough and ACE Inhibitors: The Truth Beyond Placebo.
|
29468656 |
2019 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Given the knowledge that some adverse drug reactions, such as torsade de pointes and angiotensin-converting enzyme inhibitor-induced cough, occur more frequently in women, we emphasize the need to test medications thoroughly in both sexes and explore sexual dimorphisms.
|
29916560 |
2018 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Most clinical ACE inhibitor(s) (ACEi) have been shown to inhibit both domains nonselectively, resulting in adverse effects such as cough and angioedema.
|
29206036 |
2018 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
However, ACE inhibitors remain associated with cough and a very low risk of angioedema and fatalities.
|
29598869 |
2018 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The reporting of cough with ACE inhibitors was increased with age until reaching a plateau at middle adulthood (40-59 years) and the reporting of angioedema with ACE inhibitors was increased with age until elderly (60-79 years).
|
28767167 |
2017 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Data on patients with angioedema or cough induced by ACE inhibitors were collected from the Swedish database of spontaneously reported ADRs or from collaborating clinicians.
|
27889699 |
2017 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways.
|
28084903 |
2017 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough.
|
26169577 |
2016 |
Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia.
|
26222869 |
2015 |
Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Clinical observations suggest that incidence of cough in Chinese taking angiotensin converting enzyme inhibitors is much higher than other racial groups.
|
26607661 |
2015 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
ABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough.
|
24743543 |
2014 |
Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
There was no significant association between ACE I/D polymorphism as well as the B₂ C-58T SNP with both ACE-induced AE and cough.
|
23730990 |
2013 |
Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
In our meta-analysis we did not find a significant association between the ACE insertion/deletion polymorphism and ACEI cough.
|
23394388 |
2013 |
Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Our objective was to assess the relationship between the ACE I/D polymorphism and ACEI-related cough by meta-analysis and to summarize all studies that are related to ACE I/D polymorphism and ACEI-cough and make a summary conclusion to provide reference for the researchers who attempt to conduct such a study.
|
22723835 |
2012 |
Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
We found that genetic polymorphisms in MME [rs2016848, P=0.002, odds ratio (OR)=1.795], BDKRB2 (rs8012552, P=0.012, OR=1.609), PTGER3 (rs11209716, P=0.002, OR=0.565), and ACE (rs4344) genes are associated with ACEi-related cough.
|
21052031 |
2011 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes.
|
21832968 |
2011 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Cough associated with angiotensin-converting enzyme inhibitor therapy may be more common in APIAs than in whites.
|
19302427 |
2009 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans.
|
19744011 |
2009 |
Coughing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings indicate that the Gly231Glu polymorphism is associated with a lower prevalence of ACE inhibitor-related cough.
|
19583679 |
2009 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We have reported that use of angiotensin I-converting enzyme (ACE) inhibitor, which is a class of antihypertensive agent that induces cough, is an independent factor in reducing risk of pneumonia among elderly inpatients.
|
16202861 |
2005 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
[A prospective study on the cough mechanism induced by angiotensin-converting enzyme inhibitors in patients with hypertension].
|
15498266 |
2004 |
Coughing
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
[Study on candidate genes of benazepril related cough in Chinese hypertensives].
|
12848919 |
2003 |