ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE Rate of Cough During Treatment With Angiotensin-Converting Enzyme Inhibitors: A Meta-Analysis of Randomized Placebo-Controlled Trials. 29330882 2019
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Demographic and Clinical Characteristics of Patients Presenting With Angiotensin-converting Enzyme Inhibitors Induced Cough. 31700727 2019
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE This study demonstrated that ACE I/D but not BDKRB2-58T/C polymorphism could be a predictor for the risk of ACE inhibitor-induced cough, especially in east Asians and the aged. 30672376 2019
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Cough and ACE Inhibitors: The Truth Beyond Placebo. 29468656 2019
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Given the knowledge that some adverse drug reactions, such as torsade de pointes and angiotensin-converting enzyme inhibitor-induced cough, occur more frequently in women, we emphasize the need to test medications thoroughly in both sexes and explore sexual dimorphisms. 29916560 2018
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Most clinical ACE inhibitor(s) (ACEi) have been shown to inhibit both domains nonselectively, resulting in adverse effects such as cough and angioedema. 29206036 2018
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE However, ACE inhibitors remain associated with cough and a very low risk of angioedema and fatalities. 29598869 2018
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE The reporting of cough with ACE inhibitors was increased with age until reaching a plateau at middle adulthood (40-59 years) and the reporting of angioedema with ACE inhibitors was increased with age until elderly (60-79 years). 28767167 2017
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Data on patients with angioedema or cough induced by ACE inhibitors were collected from the Swedish database of spontaneously reported ADRs or from collaborating clinicians. 27889699 2017
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways. 28084903 2017
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. 26169577 2016
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia. 26222869 2015
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE Clinical observations suggest that incidence of cough in Chinese taking angiotensin converting enzyme inhibitors is much higher than other racial groups. 26607661 2015
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE ABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough. 24743543 2014
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE There was no significant association between ACE I/D polymorphism as well as the B₂ C-58T SNP with both ACE-induced AE and cough. 23730990 2013
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE In our meta-analysis we did not find a significant association between the ACE insertion/deletion polymorphism and ACEI cough. 23394388 2013
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE Our objective was to assess the relationship between the ACE I/D polymorphism and ACEI-related cough by meta-analysis and to summarize all studies that are related to ACE I/D polymorphism and ACEI-cough and make a summary conclusion to provide reference for the researchers who attempt to conduct such a study. 22723835 2012
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE We found that genetic polymorphisms in MME [rs2016848, P=0.002, odds ratio (OR)=1.795], BDKRB2 (rs8012552, P=0.012, OR=1.609), PTGER3 (rs11209716, P=0.002, OR=0.565), and ACE (rs4344) genes are associated with ACEi-related cough. 21052031 2011
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes. 21832968 2011
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE Cough associated with angiotensin-converting enzyme inhibitor therapy may be more common in APIAs than in whites. 19302427 2009
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. 19744011 2009
CUI: C0010200
Disease: Coughing
Coughing
0.400 GeneticVariation phenotype BEFREE Our findings indicate that the Gly231Glu polymorphism is associated with a lower prevalence of ACE inhibitor-related cough. 19583679 2009
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype BEFREE We have reported that use of angiotensin I-converting enzyme (ACE) inhibitor, which is a class of antihypertensive agent that induces cough, is an independent factor in reducing risk of pneumonia among elderly inpatients. 16202861 2005
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype CTD_human [A prospective study on the cough mechanism induced by angiotensin-converting enzyme inhibitors in patients with hypertension]. 15498266 2004
CUI: C0010200
Disease: Coughing
Coughing
0.400 Biomarker phenotype CTD_human [Study on candidate genes of benazepril related cough in Chinese hypertensives]. 12848919 2003