ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Initial evidence with AD patients shows that a brain-penetrating ACE inhibitor counteracts the process of neurodegeneration and dementia. 30991105 2020
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease CTD_human We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. 30820047 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. 30820047 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Pharmacogenetics of Angiotensin-Converting Enzyme Inhibitors in Patients with Alzheimer's Disease Dementia. 29034839 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE We used multivariable-adjusted Cox proportional hazard models to assess the association of gout with a new diagnosis of dementia (incident dementia), adjusting for potential confounders/covariates including demographics (age, race, sex), comorbidities (Charlson-Romano comorbidity index), and medications commonly used for cardiac diseases (statins, beta-blockers, diuretics, and angiotensin converting enzyme (ACE)-inhibitors) and gout (allopurinol and febuxostat). 30428833 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE Our results suggest that, ApoE ε4, ACE I and PON1-L55M T alleles are associated with dementia risk whether these polymorphisms were studied separately or gathered in haplotypes. 28657841 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND). 28511735 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE This study shows the relevance of polymorphisms in APOB (odds ratio (OR), 1.17; 95% confidence interval (95% CI), 0.74-1.85), APOC3 (OR, 1.33; 95% CI, 0.82-2.17) and APOE (OR, 1.75; 95% CI, 1.09-2.80), as genetic risk markers for hypercholesterolemia; polymorphisms in ACE (OR, 1.68; 95% CI, 0.32-8.77) and AGT (OR, 1.74; 95% CI, 0.97-3.14) for hypertension; and in APOE*3/*4 (OR, 2.06; 95% CI, 1.70-2.51) and APOE*4/*4 (OR, 3.08; 95% CI, 1.85-5.12) as unambiguous markers of dementia. 29081697 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE As previously found for rs1799752 in ACE, rs5186 in AGTR1 was associated with dementia at baseline (OR: 3.25 [CI: 1.42-7.06], z = 2.90, p = 0.004). 27639288 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Other covariates in the model that were independently associated with CINA included advanced age, diabetes mellitus (DM), use of angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB), history of dementia and living in a residential care facility. 27038455 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE The Addenbrooke's Cognitive Examination III (ACE-III), an adaptation of the ACE cognitive screening test, has been demonstrated to have high sensitivity and specificity in detecting cognitive impairment in patients with dementia and other neurological and psychiatric disorders. 28865943 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE We screened 37 AD, 8 mild cognitive impairment (MCI), 3 AD and CVD (cerebrovascular disease), 3 MCI and CVD, 8 frontotemporal dementia (FTD) and 2 progressive supranuclear palsy (PSP) patients, and 28 normal controls (NCs).We sequenced PSEN1, PSEN2 and APP (EOAD risk factors), as well as MAPT, GRN and TARDBP for all cases and NCs, and analysed the APOE, CLU, CR1 and PICALM genotypes as well as the MAPT and ACE haplotypes (LOAD risk factors) for the AD (n = 37) and AD + MCI (n = 45) cases and NCs (n = 28).We identified variants in PSEN1, PSEN2 and TARDBP across a range of phenotypes (AD, AD and CVD, FTD and PSP), suggesting that screening of all known candidate genes of Alzheimer's and non-Alzheimer's forms of dementias in all dementia cases might be warranted. 26159191 2015
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE The frequency of the ACE*ins allele was also greater in the groups with Alzheimer's disease and dementia in general (P = 0.022; P = 0.045), but genotype frequencies were only different in groups without the E*4/-317*ins haplotype (P = 0.012 for Alzheimer's disease; P = 0.04 for dementia). 21533863 2011
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE This study suggests that the ACE I/D polymorphism does not have any genetic association with global or specific cognitive domain in aged men without dementia. 21833743 2011
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE Variations among reports on the relationship between the ACE ID polymorphism and dementia may be due to lack of consideration for gene-gene and gene-phenotype associations. 18838196 2010
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE Frequency of ACE D allele was seemingly high in dementia cases (26.7%) when compared to controls (11.2%). 19716217 2009
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 AlteredExpression disease BEFREE No difference in ACE levels was found between the dementia groups and controls. 17270454 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE The involvement of the ACE D/I polymorphism in the pathogenesis of DWMHs in dementia (AD and VaD), by a mechanism that is independent of its association with cardiovascular risk factors, should be confirmed in a large population-based sample. 16970648 2006
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease CTD_human Alzheimer disease risk and genetic variation in ACE: a meta-analysis. 14872014 2004
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE Apolipoprotein E, angiotensin-converting enzyme and alpha-1-antichymotrypsin genotypes are not associated with post-stroke dementia. 12736093 2003
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE There was a lack of association between presence of the D allele on the ACE gene and dementia status. 12634288 2003
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Paraoxonase, ACE, and MTHFR polymorphisms were not associated with VD or LOAD; these common polymorphisms might have a marginal role in the pathogenesis of dementia in older subjects. 11328206 2001
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE The angiotensin I converting enzyme gene as a susceptibility factor for dementia. 11402126 2001
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE Moreover, although inconsistent, several results of case-control studies tend to suggest that the ACE I/D genetic polymorphism may constitute a genetic susceptibility factor for dementia, reinforcing the hypothesis of a major implication of vascular risk factors in the occurrence of dementia. 10818534 2000