IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Published reports evaluating whether angiotensin-converting enzyme inhibitors/angiotensin receptor blocker (ACEI/ARB) therapy could bring improvements to the prognosis of immunoglobulin A nephropathy (IgAN) have yielded confusing results, which entails a systematic review of those reports.
|
30270542 |
2019 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) as the commonly used renin-angiotensin aldosterone system inhibitor are widely used in patients with IgA nephropathy (IgAN), but the effect is controversy.
|
31700813 |
2019 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Only angiotensin-converting enzyme inhibitors (ACE-I)/angiotensin-receptor blockers (ARB) show a high level of evidence (1B level) of being of value in the treatment for IgAN according to the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.
|
28395659 |
2017 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ACE I/D predicted the IgAN progression and the renoprotective effect of RAS blockade in IgAN patients whereas neither AT1R A1166C nor AGT T704C did.
|
24452035 |
2015 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Paired t test showed no significant (P > 0.05) differences of alpha-diversity parameters (OTU, ACE, Chao1, and Shannon index) between the salivary samples of HC and IgAN patients.
|
25763757 |
2015 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients.
|
23060471 |
2013 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was a difference in ACE gene type II and type I between the IgAN and MN groups (P < .05) and in eNOS gene TT type and T type between the IgAN and MN groups (P < .05 and P < .01).
|
24157068 |
2013 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data did not support a link between the ACE D allele or DD genotype and IgAN progression in Asians and Caucasians (Asians: D: OR = 1.03, p = 0.80; DD: OR = 1.43, p = 0.16; Caucasians: D: OR = 1.29, p = 0.22; DD: OR = 1.31, p = 0.17).
|
21357308 |
2011 |
IGA Glomerulonephritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduced ACE2 expression (p < 0.01) and increased ACE expression in glomeruli (p < 0.001), and reduced ACE2 expression in tubulointerstitium (p < 0.001) were observed in patients with IgA nephropathy compared to healthy controls, although the changes in ACE2 mRNA were not statistically significant.
|
20689326 |
2011 |
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ACE gene was sequenced in four healthy Chinese subjects and 20 patients with IgA nephropathy (IgAN) to observe if differences exist among SNPs and haplotypes.
|
22173253 |
2011 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, the aldosterone synthase (CYP11B2) gene, C-344T, and the angiotensin II type 1 receptor (AT1R) gene, A1166C, have been shown to be associated with IgA nephropathy (IgAN) and its progression.
|
21163122 |
2010 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We compared the clinical characteristics, histological findings, and genotypes of the angiotensin-converting enzyme (ACE) gene and plasminogen activator inhibitor-1 gene between IgAN and N-IgAN patients.
|
19937361 |
2010 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A synergistic association of ACE I/D and eNOS G894T gene variants with the progression of immunoglobulin A nephropathy - a pilot study.
|
19546528 |
2009 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of angiotensin-converting enzyme gene polymorphism on the progression of immunoglobulin A nephropathy in Malaysian patients.
|
19037561 |
2008 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given that IgAN is usually characterized by mesangioproliferative glomerulonephritis and that PDGF-B is of central pathophysiological relevance in this process, we analyzed four single-nucleotide polymorphisms (SNPs) of the PDGF-B gene to evaluate a possible association of these SNPs with disease onset and progression, histological grading and responses to ACE inhibitor (ACEi) therapy.
|
17338425 |
2007 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The meta-analysis was performed to assess the correlation between the pattern of ACE gene polymorphism and progression of IgAN.
|
17162429 |
2006 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis was performed to assess the correlation between the pattern of ACE gene polymorphism and progression of IgAN.
|
17162429 |
2006 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of angiotensin I-converting enzyme gene insertion/deletion polymorphism and IgA nephropathy: a meta-analysis.
|
17124384 |
2006 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our findings support the notion that ACE I/D polymorphism is associated with IgAN.
|
17124384 |
2006 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the impact of the three major genetic polymorphisms of the renin-angiotensin system [angiotensinogen (AGT) gene M235T, angiotensin-converting enzyme (ACE) gene-I/D and angiotensin II-type 1 receptor (AT1R) gene A1166C polymorphisms] as risk factors in IgA nephropathy.
|
15031629 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among the ACE, AGT and ATR gene polymorphisms, only the DD genotype may predispose the individual to IgAN in our Chinese population.
|
15153745 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have previously reported that the TT genotype of the angiotensinogen gene and the ID/DD genotype of the angiotensin-converting enzyme gene are associated with increased severity of proteinuria in IgA nephropathy in Japanese children.
|
14648325 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The PAI-1 and ACE polymorphisms were examined in 270 healthy volunteers and 202 biopsy-proven IgAN patients, including 117 untreated IgAN patients who had an annual health check, allowing an estimation of the time of onset of overt proteinuria and/or hematuria.
|
15481848 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, and the angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with IgA nephropathy (IgAN) and its progression.
|
15504143 |
2004 |
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we evaluated the clinical manifestations and renal prognosis in 276 Japanese patients with histologically proven IgAN with respect to their ACE I/D and ADD1 G460W polymorphisms.
|
12885793 |
2003 |