Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
ACE activity was determined in the serum and in selected brain regions of an animal model presenting SCZ-like behaviour, before and after the treatment with typical and atypical antipsychotics, and also in the serum of animals receiving the psychostimulants amphetamine/lisdexamphetamine.
|
30806143 |
2019 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abnormal activity of two enzymes relevant to neurodevelopment, namely nuclear-distribution element-like 1 (Ndel1) and angiotensin I-converting enzyme (ACE), was reported in individuals with schizophrenia; to our knowledge, these oligopeptidases were never measured in bipolar disorder (BD).
|
30321766 |
2019 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with individuals with diabetes only, those with diabetes and schizophrenia were less likely to receive high-quality diabetes care (relative risk [RR]=.91, 95% confidence interval [CI]=.88-.95) and less likely to receive several individual process performance measures of diabetes care, including blood pressure monitoring (RR=.98, CI=.96-.99), treatment with antihypertensive drugs (RR=.83, CI=.70-.97) and angiotensin-converting enzyme/angiotensin II receptor inhibitors (RR=.72, CI=.55-.93), screening for albuminuria (RR=.96, CI=.93-.99), eye examination at least once every second year (RR=.97, CI=.94-.99), and foot examination (RR=.96, CI=.93-.99).
|
29032706 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These 11 therapies were for patients with heart failure (angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, aldosterone receptor antagonists and digoxin), stable coronary artery disease (intensive statin therapy), asthma exacerbations (early inhaled corticosteroids in the emergency department and anticholinergics), chronic obstructive pulmonary disease (long-acting muscarinic antagonists and long-acting beta-2 adrenoceptor agonists) and schizophrenia (second-generation antipsychotics and depot/maintenance antipsychotics).
|
30045724 |
2018 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th-75th percentiles) = 434.79 (341.15-524.02) vs. 508.49 (396.34-608.72); p < 0.05].
|
29925475 |
2018 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the ACE-I/D polymorphism may be relevant in determining the risk of nicotine dependence in female patients with schizophrenia while the ACE genotype-smoking interaction does not contribute to the clinical expression of schizophrenia.
|
28028641 |
2017 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have revealed the association of the ACE gene insertion/deletion polymorphism with depressive disorder and its treatment response but not with the depressive symptoms in schizophrenia.
|
25694211 |
2015 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis found no association between the ACE I/D polymorphism and schizophrenia or PD.
|
25143327 |
2015 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Previous studies have revealed the association of the ACE gene insertion/deletion polymorphism with depressive disorder and its treatment response but not with the depressive symptoms in schizophrenia.
|
25694211 |
2015 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients.
|
26296754 |
2015 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, we found that the difference between the measured ACE activity for each SCZ patient and the expected average mean value for each respective genotype group (for control subjects) was a better predictor of SCZ than the ACE dichotomized values (high/low) or ACE I/D.
|
25701466 |
2015 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and first-episode patients with schizophrenia in a Chinese Han population.
|
24615782 |
2014 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and first-episode patients with schizophrenia in a Chinese Han population.
|
24615782 |
2014 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The present study aimed at detecting the incidence of ACE gene I/D polymorphism in patients with schizophrenia living in the Eskisehir region (Turkey) and also at determining whether this illness could be associated to ACE gene I/D polymorphism and serum ACE concentrations.
|
21158679 |
2010 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
As SZ and BD have some susceptibility genes in common and since unaffected first-degree relatives of these patients carry a high likelihood of these susceptibility genes, we aimed to elucidate the role of angiotensin-converting enzyme (ACE) genetic variants in patients with SZ, BD and their first-degree relatives.
|
20010451 |
2010 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
It was observed that serum ACE concentrations significantly increased in patients with schizophrenia compared with those of the control group (p < 0.05).
|
21158679 |
2010 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ACE insertion/deletion polymorphism was associated with SZ and BD.
|
20010451 |
2010 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that the ACE D allele is involved in the development of schizophrenia.
|
18986708 |
2009 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The D allele of the ACE gene was identified as a protective factor, significantly reducing the risk of developing schizophrenia and related disorders (by 40%) and of developing schizophrenia (by 50%).
|
18986708 |
2009 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We present a schizophrenia association study using an extensive linkage disequilibrium (LD) mapping approach in seven candidate genes with a well established link to dopamine, including receptors (DRD2, DRD3) and genes involved in its metabolism and transport (ACE, COMT, DAT, MAO-A, MAO-B).
|
19508883 |
2009 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The ACE I/D polymorphism showed no association with polydipsic schizophrenia.
|
15978554 |
2005 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship of COMT and ACE gene polymorphism with response to conventional neuroleptic treatment in schizophrenia.
|
12729939 |
2003 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequently, we examined the genetic association between polydipsia/water intoxication and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism in patients with chronic schizophrenia (polydipsics: n = 65; non-polydipsics: n = 97) because several lines of evidence suggested that ACE might be involved in the development of polydipsia in schizophrenia.
|
12707930 |
2003 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Subsequently, we examined the genetic association between polydipsia/water intoxication and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism in patients with chronic schizophrenia (polydipsics: n = 65; non-polydipsics: n = 97) because several lines of evidence suggested that ACE might be involved in the development of polydipsia in schizophrenia.
|
12707930 |
2003 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87).
|
11920854 |
2002 |