DEFA4, defensin alpha 4, 1669

N. diseases: 5; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.300 GeneticVariation disease UNIPROT
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.010 AlteredExpression disease BEFREE A lack of expression of DEFA4 could be a potential indicator of periodontitis status. 29446150 2018
CUI: C2347126
Disease: Microscopic Polyarteritis
Microscopic Polyarteritis 		0.010 Biomarker disease BEFREE We earlier nominated 16 genes (IRF7, IFIT1, IFIT5, OASL, CLC, GBP-1, PSMB9, HERC5, CCR1, CD36, MS4A4A, BIRC4BP, PLSCR1, DEFA1/DEFA3, DEFA4, and COL9A2) as predictors of response to remission induction therapy against MPA. 28569178 2017
CUI: C0026277
Disease: Mixed Salivary Gland Tumor
Mixed Salivary Gland Tumor 		0.010 AlteredExpression disease BEFREE In comparison with healthy tissue, the gene expression of DEFA 1/3 and 4 was significantly (p<0.05) increased in all tumours - except for a significant decrease of DEFA 4 gene expression in pleomorphic adenomas and a similar transcript level for DEFA 1/3 compared to healthy salivary glands. 23050799 2012
CUI: C0025303
Disease: Meningococcal Infections
Meningococcal Infections 		0.010 Biomarker group BEFREE Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1, and DEFA4 in meningococcal disease in three populations. 20016407 2010