Doughnut Lesions of Skull, Familial
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2.
|
30779713 |
2019 |
Doughnut Lesions of Skull, Familial
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Osteoporosis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
SGMS2 pathogenic variants underlie a spectrum of skeletal conditions, ranging from isolated osteoporosis to complex skeletal dysplasia, suggesting a critical role for plasma membrane-bound sphingomyelin metabolism in skeletal homeostasis.
|
30779713 |
2019 |
Osteoporosis
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
Dental caries
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Scoliosis, unspecified
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Alkaline phosphatase raised
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Serum alkaline phosphatase raised
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Thickened calvaria
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Increased fracture rate
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Arteriosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
The preliminary molecular mechanism-of-action studies revealed its function in lipid homeostasis and inflammation process, which indicated that the selective inhibition of SMS2 would be a promising treatment for atherosclerosis.
|
30580239 |
2019 |
Atherosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
The preliminary molecular mechanism-of-action studies revealed its function in lipid homeostasis and inflammation process, which indicated that the selective inhibition of SMS2 would be a promising treatment for atherosclerosis.
|
30580239 |
2019 |
Arteriosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
Sphingomyelin synthase 2 (SMS2) is a promising therapeutic target for several chronic inflammation-associated diseases, including atherosclerosis, fatty liver, and insulin resistance.
|
30074791 |
2018 |
Atherosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
Sphingomyelin synthase 2 (SMS2) is a promising therapeutic target for several chronic inflammation-associated diseases, including atherosclerosis, fatty liver, and insulin resistance.
|
30074791 |
2018 |
Arteriosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
It was reported that SMS2 KO mice displayed lower inflammatory responses and anti-atherosclerotic effects, suggesting that inhibition of SMS2 would be a potential therapeutic approach for controlling inflammatory responses and atherosclerosis.
|
28505533 |
2017 |
Arteriosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
SMS2 could serve as a promising therapeutic target for atherosclerosis.
|
28619536 |
2017 |
Atherosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
SMS2 could serve as a promising therapeutic target for atherosclerosis.
|
28619536 |
2017 |
Atherosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
It was reported that SMS2 KO mice displayed lower inflammatory responses and anti-atherosclerotic effects, suggesting that inhibition of SMS2 would be a potential therapeutic approach for controlling inflammatory responses and atherosclerosis.
|
28505533 |
2017 |
Arteriosclerosis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
This study sought to assess the effect of sphingomyelin synthase 2 (SMS2) over-expression on plaque component and endothelial dysfunction in atherosclerosis.
|
22538014 |
2012 |
Atherosclerosis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
This study sought to assess the effect of sphingomyelin synthase 2 (SMS2) over-expression on plaque component and endothelial dysfunction in atherosclerosis.
|
22538014 |
2012 |
Arteriosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
SMS2 could be a potential target for treating atherosclerosis.
|
21235823 |
2011 |
Atherosclerosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
SMS2 could be a potential target for treating atherosclerosis.
|
21235823 |
2011 |
Arteriosclerosis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We therefore believe that regulation of liver SMS2 activity could become a promising treatment for atherosclerosis.
|
19286635 |
2009 |
Atherosclerosis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We therefore believe that regulation of liver SMS2 activity could become a promising treatment for atherosclerosis.
|
19286635 |
2009 |