Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333704
Disease: Chromosome Breaks
Chromosome Breaks
0.300 Biomarker phenotype CTD_human DNA fragmentation factor 40 expression in T cells confers sensibility to tributyltin-induced apoptosis. 31401084 2019
CUI: C0376628
Disease: Chromosome Breakage
Chromosome Breakage
0.300 Biomarker phenotype CTD_human DNA fragmentation factor 40 expression in T cells confers sensibility to tributyltin-induced apoptosis. 31401084 2019
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker disease RGD Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. 11425895 2001
Corpuscular Hemoglobin Concentration Mean
0.100 GeneticVariation phenotype GWASDB Seventy-five genetic loci influencing the human red blood cell. 23222517 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE Women with DFF40- and BCL2-negative tumors had higher risks of disease recurrence, lymph node involvement, lympho-vascular space infiltration, and deep myometrial invasion compared with women with DFF40- and BCL2-positive tumors. 29653556 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE In summary, our experimental evidences suggest that scutellarein has strong potentiality to attenuate the tumor development by modulating sprouting neovasculature and DFF-40 mediated apoptosis. 28104392 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 AlteredExpression group BEFREE Disruption of DFF40 and DFF45 expression was observed in uLMS, but not in uLM or control and case myometrium; this may play a role in tumor pathogenesis. 29075126 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 AlteredExpression group BEFREE Only the DFFB gene demonstrated decreased expression in all tumor pairs tested. 16156899 2005
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 GeneticVariation group BEFREE Since the putative neuroblastoma tumour suppressor gene in distal 1p36 is predicted to be maternally expressed, the lack of imprinting and absence of somatic mutations in DFFB indicate that it is probably not the neuroblastoma tumour suppressor gene. 10830907 2000
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.040 Biomarker group BEFREE Endometrial Polyps and Benign Endometrial Hyperplasia Have Increased Prevalence of DNA Fragmentation Factors 40 and 45 (DFF40 and DFF45) Together With the Antiapoptotic B-Cell Lymphoma (Bcl-2) Protein Compared With Normal Human Endometria. 28914671 2018
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.040 Biomarker group BEFREE Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression. 29653556 2018
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.040 Biomarker group BEFREE DNA fragmentation factors 40 and 45 (DFF40 and DFF45) are final executors of apoptosis, and B-cell lymphoma 2 (Bcl-2) is a well-recognized apoptosis inhibitor. 30393479 2018
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.040 Biomarker group BEFREE DNA fragmentation factors 40 and 45 (DFF40 and DFF45) are responsible for final DNA-laddering during apoptosis, whereas Bcl-2 (B-cell lymphoma 2) is an apoptosis inhibitor. 29075126 2017
CUI: C0023269
Disease: leiomyosarcoma
leiomyosarcoma
0.020 Biomarker disease BEFREE Moreover, DF45, BCL2 and DFF40 underexpression has been reported in numerous malignancies, including uterine leiomyosarcomas. 29653556 2018
CUI: C0023269
Disease: leiomyosarcoma
leiomyosarcoma
0.020 AlteredExpression disease BEFREE DNA fragmentation factors 40 and 45 (DFF40/DFF45) and B-cell lymphoma 2 (Bcl-2) protein are underexpressed in uterine leiomyosarcomas and may predict survival. 29075126 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.020 GeneticVariation disease BEFREE High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma. 16007181 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.020 GeneticVariation disease LHGDN High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma. 16007181 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.020 GeneticVariation disease LHGDN Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells. 12610505 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE Moreover, DF45, BCL2 and DFF40 underexpression has been reported in numerous malignancies, including uterine leiomyosarcomas. 29653556 2018
CUI: C0023418
Disease: leukemia
leukemia
0.010 GeneticVariation disease BEFREE Apoptotic nuclease, caspase-activated deoxyribonuclease (CAD) has been implicated in mediating translocation in leukaemia. 29649994 2018
CUI: C0156369
Disease: Uterine Polyp
Uterine Polyp
0.010 Biomarker disease BEFREE In this study, we aimed to investigate DFF40, DFF45, and Bcl-2 immunoexpression in endometrial polyps (EPs) and benign endometrial hyperplasia (BEH) tissue compared with that in normal proliferative endometrium (NPE) and normal secretory endometrium (NSE) as well as normal post menopausal endometrium (NAE). 28914671 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.010 AlteredExpression disease BEFREE Immunohistochemistry was performed to evaluate DFF45, BCL2 and DFF40 expression in 342 cases of ECs. 29653556 2018
CUI: C2712711
Disease: Benign endometrial hyperplasia
Benign endometrial hyperplasia
0.010 Biomarker disease BEFREE In this study, we aimed to investigate DFF40, DFF45, and Bcl-2 immunoexpression in endometrial polyps (EPs) and benign endometrial hyperplasia (BEH) tissue compared with that in normal proliferative endometrium (NPE) and normal secretory endometrium (NSE) as well as normal post menopausal endometrium (NAE). 28914671 2018
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma
0.010 GeneticVariation disease BEFREE We hypothesised that BA-induced apoptosis may cause chromosome breaks mediated by CAD leading to chromosome rearrangement in NPC. 29649994 2018
CUI: C0023267
Disease: Fibroid Tumor
Fibroid Tumor
0.010 Biomarker disease BEFREE Negative DFF40 and Bcl-2, but not DFF45, staining was a predictor of poorer DFS and OS in women with uLMS. uLM showed DFF40 and Bcl-2 overexpression compared with uM and uLM-M, with a significant positive correlation between DFF40 and DFF45. 29075126 2017