Chromosome Breaks
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
DNA fragmentation factor 40 expression in T cells confers sensibility to tributyltin-induced apoptosis.
|
31401084 |
2019 |
Chromosome Breakage
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
DNA fragmentation factor 40 expression in T cells confers sensibility to tributyltin-induced apoptosis.
|
31401084 |
2019 |
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures.
|
11425895 |
2001 |
Corpuscular Hemoglobin Concentration Mean
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Seventy-five genetic loci influencing the human red blood cell.
|
23222517 |
2012 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Women with DFF40- and BCL2-negative tumors had higher risks of disease recurrence, lymph node involvement, lympho-vascular space infiltration, and deep myometrial invasion compared with women with DFF40- and BCL2-positive tumors.
|
29653556 |
2018 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In summary, our experimental evidences suggest that scutellarein has strong potentiality to attenuate the tumor development by modulating sprouting neovasculature and DFF-40 mediated apoptosis.
|
28104392 |
2017 |
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Disruption of DFF40 and DFF45 expression was observed in uLMS, but not in uLM or control and case myometrium; this may play a role in tumor pathogenesis.
|
29075126 |
2017 |
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Only the DFFB gene demonstrated decreased expression in all tumor pairs tested.
|
16156899 |
2005 |
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Since the putative neuroblastoma tumour suppressor gene in distal 1p36 is predicted to be maternally expressed, the lack of imprinting and absence of somatic mutations in DFFB indicate that it is probably not the neuroblastoma tumour suppressor gene.
|
10830907 |
2000 |
B-Cell Lymphomas
|
0.040 |
Biomarker
|
group |
BEFREE |
Endometrial Polyps and Benign Endometrial Hyperplasia Have Increased Prevalence of DNA Fragmentation Factors 40 and 45 (DFF40 and DFF45) Together With the Antiapoptotic B-Cell Lymphoma (Bcl-2) Protein Compared With Normal Human Endometria.
|
28914671 |
2018 |
B-Cell Lymphomas
|
0.040 |
Biomarker
|
group |
BEFREE |
Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression.
|
29653556 |
2018 |
B-Cell Lymphomas
|
0.040 |
Biomarker
|
group |
BEFREE |
DNA fragmentation factors 40 and 45 (DFF40 and DFF45) are final executors of apoptosis, and B-cell lymphoma 2 (Bcl-2) is a well-recognized apoptosis inhibitor.
|
30393479 |
2018 |
B-Cell Lymphomas
|
0.040 |
Biomarker
|
group |
BEFREE |
DNA fragmentation factors 40 and 45 (DFF40 and DFF45) are responsible for final DNA-laddering during apoptosis, whereas Bcl-2 (B-cell lymphoma 2) is an apoptosis inhibitor.
|
29075126 |
2017 |
leiomyosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, DF45, BCL2 and DFF40 underexpression has been reported in numerous malignancies, including uterine leiomyosarcomas.
|
29653556 |
2018 |
leiomyosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
DNA fragmentation factors 40 and 45 (DFF40/DFF45) and B-cell lymphoma 2 (Bcl-2) protein are underexpressed in uterine leiomyosarcomas and may predict survival.
|
29075126 |
2017 |
Liver carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma.
|
16007181 |
2005 |
Liver carcinoma
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma.
|
16007181 |
2005 |
Liver carcinoma
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells.
|
12610505 |
2003 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Moreover, DF45, BCL2 and DFF40 underexpression has been reported in numerous malignancies, including uterine leiomyosarcomas.
|
29653556 |
2018 |
leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Apoptotic nuclease, caspase-activated deoxyribonuclease (CAD) has been implicated in mediating translocation in leukaemia.
|
29649994 |
2018 |
Uterine Polyp
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to investigate DFF40, DFF45, and Bcl-2 immunoexpression in endometrial polyps (EPs) and benign endometrial hyperplasia (BEH) tissue compared with that in normal proliferative endometrium (NPE) and normal secretory endometrium (NSE) as well as normal post menopausal endometrium (NAE).
|
28914671 |
2018 |
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry was performed to evaluate DFF45, BCL2 and DFF40 expression in 342 cases of ECs.
|
29653556 |
2018 |
Benign endometrial hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to investigate DFF40, DFF45, and Bcl-2 immunoexpression in endometrial polyps (EPs) and benign endometrial hyperplasia (BEH) tissue compared with that in normal proliferative endometrium (NPE) and normal secretory endometrium (NSE) as well as normal post menopausal endometrium (NAE).
|
28914671 |
2018 |
Nasopharyngeal carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We hypothesised that BA-induced apoptosis may cause chromosome breaks mediated by CAD leading to chromosome rearrangement in NPC.
|
29649994 |
2018 |
Fibroid Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Negative DFF40 and Bcl-2, but not DFF45, staining was a predictor of poorer DFS and OS in women with uLMS. uLM showed DFF40 and Bcl-2 overexpression compared with uM and uLM-M, with a significant positive correlation between DFF40 and DFF45.
|
29075126 |
2017 |