NQO1, NAD(P)H quinone dehydrogenase 1, 1728

N. diseases: 368; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.330 AlteredExpression disease BEFREE The results showed a significant rise in creatinine, urea, and cystatin C (cys C) levels and upregulation of p38 mRNA, whereas a significant decline in NAD(P)H quinone oxidoreductase 1 (NQO-1) protein and downregulation of B-cell lymphoma-2 (Bcl-2) mRNA and vascular endothelial growth factor (VEGF) mRNA were recorded in AKI. 30976980 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.330 Biomarker disease BEFREE These findings suggest that NQO1 deletion might be associated with decreased MRN complex expression, which might be partially responsible for the exacerbation of cisplatin-induced AKI in the absence of NQO1. 26723870 2016
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.330 Biomarker disease BEFREE In vivo, NQO1-KO mice displayed a significant increase in cisplatin-induced acute kidney injury (AKI), as indicated by elevated tubular damage and apoptosis as well as by suppressed cytoprotective signals. 26935540 2016
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.330 Biomarker disease CTD_human These findings suggest that NQO1 deletion might be associated with decreased MRN complex expression, which might be partially responsible for the exacerbation of cisplatin-induced AKI in the absence of NQO1. 26723870 2016