DPYD, dihydropyrimidine dehydrogenase, 1806

N. diseases: 249; N. variants: 101
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.320 AlteredExpression group BEFREE Recent studies showed that the mutations in EGFR is associated with high expression of dihydropyrimidine dehydrogenase, which is an inactivating and rate-limiting enzyme for fluoropyrimidine, and suggested that the combination of chemotherapy with fluoropyrimidine and EGFR-targeting agents is effective against EGFR-overexpressing gastric tumors, while ANXA3 overexpression confers resistance to tyrosine kinase inhibitors targeting the EGFR pathway. 26475168 2015
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.320 Biomarker group CTD_human Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer. 18652704 2008
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.320 Biomarker group CTD_human The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance. 17089033 2006
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.320 Biomarker group CTD_human Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients. 15837757 2005
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.320 AlteredExpression group LHGDN Comparative analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in gastric and colorectal cancers. 15069545 2004