DRD2, dopamine receptor D2, 1813

N. diseases: 437; N. variants: 42
Disease: Cocaine Abuse ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 GeneticVariation disease BEFREE One functional single nucleotide polymorphism in dopamine receptor D2 (DRD2), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre- and postsynaptically. rs1076560 has been previously associated with cocaine abuse and we set out to confirm this association in a sample of European American (EA) (n = 336) and African American (AA) (n = 1034) cocaine addicts and EA (n = 656) and AA (n = 668) controls. 24359476 2014
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease PSYGENET One functional single nucleotide polymorphism in dopamine receptor D2 (DRD2), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre- and postsynaptically. rs1076560 has been previously associated with cocaine abuse and we set out to confirm this association in a sample of European American (EA) (n = 336) and African American (AA) (n = 1034) cocaine addicts and EA (n = 656) and AA (n = 668) controls. 24359476 2014
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease PSYGENET Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction. 23340505 2013
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease BEFREE ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. 23635803 2013
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease PSYGENET ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. 23635803 2013
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 GeneticVariation disease BEFREE Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction. 23340505 2013
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease PSYGENET To assess the role of DRD2 variants in cocaine abuse, we measured levels of D2S and D2L mRNA in human brain autopsy tissues (prefrontal cortex and putamen) obtained from cocaine abusers and controls, and genotyped a panel of DRD2 SNPs (119 abusers and 95 controls). 21150907 2011
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 GeneticVariation disease BEFREE To assess the role of DRD2 variants in cocaine abuse, we measured levels of D2S and D2L mRNA in human brain autopsy tissues (prefrontal cortex and putamen) obtained from cocaine abusers and controls, and genotyped a panel of DRD2 SNPs (119 abusers and 95 controls). 21150907 2011
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. 18418874 2008
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. 18418874 2008
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. 16541082 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. 16541082 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 16971900 2006
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 16971900 2006
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. 15010698 2004
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. 15042275 2004
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. 15042275 2004
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. 15010698 2004
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Therapeutic disease CTD_human Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. 11751029 2002
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.540 Biomarker disease CTD_human Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. 11923462 2002