|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that overlapping expressions of CB1 and D2R is the cause of CB1-D2R interactions in cases of substance abuse and the different polymorphisms of CNR1 and DRD2 genes may have decisive roles in the nature of these interactions in terms of promoting or alleviating the cannabis addiction risk factor of the individual.
|
26833047 |
2016 |
|
Substance abuse problem
|
0.400 |
Biomarker
|
disease |
CTD_human |
Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward.
|
16901644 |
2006 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The A1 allele of the dopamine D2 receptor gene (DRD2) is associated with a reduced number of dopamine binding sites in the brain and with the increased likelihood of substance abuse and addictive behavior.
|
15492764 |
2005 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial.
|
15184239 |
2004 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results indicate that both sex and DRD2 genotype modify associations between negative affect and other substance abuse risk markers.
|
13679114 |
2003 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In effect, one form of the DRD2 gene, the A1 allele, renders the dopaminergic system inefficient and rewards substance abuse that increases brain dopamine levels.
|
10881203 |
2000 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some series of investigations hold promise that a trait marker for a particular subset of alcoholics may be developed, e.g. severe alcoholism and the dopamine D2 receptor gene; the level of reaction to alcoholism in family history-positive alcoholics; beta-endorphin abnormalities in specific family groups of alcoholics; reduced P3 wave event-related potentials as markers and predictors of development of substance abuse in predisposed youths; reduced growth hormone response to apomorphine as a predictor of relapse to alcoholism in early abstinence; abnormal adenylyl cyclase activity in certain defined subgroups of alcoholics; and abnormal platelet monoamine oxidase levels in subjects with a behavioural predisposition to addictive disorders.
|
10528806 |
1999 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse.
|
9650635 |
1998 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several lines of evidence suggest that presence of a D2 dopamine receptor (DRD2) gene variant marked by TaqI restriction fragment length polymorphisms (RFLPs) might contribute to vulnerability to substance abuse.
|
8894071 |
1996 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Dopamine D2 receptor gene (DRD2) haplotypes and the defense style questionnaire in substance abuse, Tourette syndrome, and controls.
|
7647164 |
1995 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The dopamine D2 receptor gene: a genetic risk factor in substance abuse.
|
8033754 |
1994 |
|
Substance abuse problem
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our work suggests an association of polymorphisms of the DRD2 gene and a biological marker previously indicated to have predictive value in vulnerability to substance abuse.
|
7704037 |
1994 |
|
Substance abuse problem
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The restriction fragment length polymorphism (RFLP) markers TaqIA1 and B1 at the dopamine D2 receptor (DRD2) gene locus in Caucasians are associated with substance abuse behaviors.
|
7681236 |
1993 |
|
Substance abuse problem
|
0.400 |
Biomarker
|
disease |
BEFREE |
If further studies continue to support the results currently at hand, they would indicate that the DRD2 gene is the most prominent single gene determinant of susceptibility to severe substance abuse.
|
8512526 |
1993 |