DRD2, dopamine receptor D2, 1813

N. diseases: 437; N. variants: 42
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease BEFREE Compared with dopamine D2 receptor antagonism that is exhibited by most antipsychotics, partial agonism may result in improved outcomes in major depressive disorder and in schizophrenia. 31406978 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 GeneticVariation disease GWASCAT Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. 29942085 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 GeneticVariation disease BEFREE TPH, SLC6A2, SLC6A3, DRD2 and DRD4 Polymorphisms and Neuroendocrine Factors Predict SSRIs Treatment Outcome in the Chinese Population with Major Depression. 25642918 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 GeneticVariation disease BEFREE Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. 24555772 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease PSYGENET Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. 24555772 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease PSYGENET Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain. 24322206 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease PSYGENET DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. 23683269 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 GeneticVariation disease BEFREE DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. 23683269 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease BEFREE However, we could detect no evidence of genetic association between 3 markers in DRD2 and major depressive disorder in the Chinese Han population. 23696934 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease PSYGENET However, we could detect no evidence of genetic association between 3 markers in DRD2 and major depressive disorder in the Chinese Han population. 23696934 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 GeneticVariation disease BEFREE The results suggest that the DRD2 gene may play a role on MDD susceptibility and the onset-time of antidepressant response. 22796099 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease PSYGENET The results suggest that the DRD2 gene may play a role on MDD susceptibility and the onset-time of antidepressant response. 22796099 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 GeneticVariation disease BEFREE Dopamine 2 receptor gene (DRD2) polymorphism rs6277" genes_norm="1813">C957T (rs6277) and cathechol-o-methyltransferase (COMT) polymorphism rs4680" genes_norm="1312">Val158Met (rs4680) interaction was studied in 118 patients suffering from major depressive disorder (MDD) treated with ECT and 383 healthy controls. 18929622 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 Biomarker disease BEFREE SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally significant associations with MDD. 15927089 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.490 GeneticVariation disease BEFREE These data indicate that MWA, anxiety disorders, and major depression can be components of a distinct clinical syndrome associated with allelic variations within the DRD2 gene. 9513185 1998