AGT, angiotensinogen, 183

N. diseases: 765; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 AlteredExpression disease BEFREE Urinary MMP-7 level outperformed (C statistic, 0.78) levels of urinary angiotensinogen (C statistic, 0.75), epidermal growth factor (C statistic, 0.75), kidney injury molecule 1 (C statistic, 0.68), and serum galactose-deficient IgA1 (C statistic, 0.59) for predicting IgAN progression. 31606236 2020
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE The AGT (M268T) genotypes were distributed in IgAN as CC 61.9%, CT 34.8%, and TT 3.2%, while in controls CC 64.1%, CT 31.3%, and TT 4.6%. 26588355 2015
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE In conclusion, AGT M235T gene polymorphism may not be correlated with IgAN susceptibility in overall populations, Caucasians and Asians. 24344785 2014
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE The ACE, AGT, and eNOS genes were correlated with the development of renal function failure in IgAN, whereas the ACE and eNOS genes were associated with the degree of proteinuria and the development of renal function failure in MN. 24157068 2013
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE We investigated the association of polymorphisms of the genes encoding major angiotensin II-forming enzymes with the development and progression of IgAN among Korean patients. 21150220 2011
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone. 21974877 2011
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, the aldosterone synthase (CYP11B2) gene, C-344T, and the angiotensin II type 1 receptor (AT1R) gene, A1166C, have been shown to be associated with IgA nephropathy (IgAN) and its progression. 21163122 2010
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE Human proximal tubular epithelial cells (PTEC) were pretreated with PPAR-gamma agonist, rosiglitazone, and/or angiotensin II (AngII) type 1 receptor (ATR1) blocker (ARB), losartan, followed by activation with the conditioned medium collected from human mesangial cells incubated with pIgA1 (IgA-HMC) from patients with IgAN. 19443277 2009
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Our results suggest that the AGT M235T polymorphism is associated with the progression of IgAN in Korean male patients. 19729965 2009
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 AlteredExpression disease BEFREE These data suggest that activated glomerular AGT expression is likely involved in elevated local ang II production and, thereby, may contribute to increased TGF-beta production and development of glomerular injury in IgAN. 18421480 2008
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 AlteredExpression disease LHGDN Immunohistochemistry showed that AGT protein was highly expressed by glomerular endothelial cells (GEC) and mesangial cells in nephritic glomeruli of IgAN compared with glomeruli of MGA. 18421480 2008
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE The current approach to suppress the effects of angiotensin II, by angiotensin-converting enzyme inhibitors, angiotensin II receptor type 1 blockers, or both, as a cornerstone of the therapy of IgA nephropathy has been strengthened by recent studies. 15202611 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, and the angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with IgA nephropathy (IgAN) and its progression. 15504143 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Recently it was reported that polymorphism at -20 from adenine to cytosine in the angiotensinogen gene, increasing the level of this transcript, was associated with the progression of renal dysfunction in adult IgA nephropathy. 14648325 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Our results suggest that angiotensinogen-M235T polymorphism is an important marker of progression in IgA nephropathy in Caucasian patients, especially when analyzed in combination with ACE-I/D polymorphism. 15031629 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Among the ACE, AGT and ATR gene polymorphisms, only the DD genotype may predispose the individual to IgAN in our Chinese population. 15153745 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE Preliminary studies showed a reduced glomerular gene expression of angiotensin II subtype 1 receptor (AT1R), suggesting a regulatory response to high intrarenal angiotensin II (Ang II) concentration in IgAN. 15458433 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease LHGDN Recently it was reported that polymorphism at -20 from adenine to cytosine in the angiotensinogen gene, increasing the level of this transcript, was associated with the progression of renal dysfunction in adult IgA nephropathy. 14648325 2004
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease LHGDN We investigated whether the therapeutic efficacy of angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin receptor blocker on renal prognosis is modified by the angiotensinogen gene (AGT) polymorphism in immunoglobulin A nephropathy (IgAN). 12911556 2003
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE We investigated whether the therapeutic efficacy of angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin receptor blocker on renal prognosis is modified by the angiotensinogen gene (AGT) polymorphism in immunoglobulin A nephropathy (IgAN). 12911556 2003
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 Biomarker disease BEFREE The effects of pIgA1 on the RAS were further examined in HMC incubated with IgA isolated from 30 patients with IgAN, 30 healthy subjects, and disease control subjects with other diseases. pIgA1 induction of angiotensin II or TGF-beta synthesis in HMC was significantly greater with preparations from patients with IgAN, compared with healthy or disease control subjects. 14638911 2003
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE A(-20)C polymorphism of the angiotensinogen gene and progression of IgA nephropathy. 12164881 2002
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Thus, the TT genotype of the AGT gene and the ID/DD genotype of the ACE gene are associated with increased severity of proteinuria, suggesting that AGT and ACE gene polymorphisms may play a significant role in the progression of IgA nephropathy in Japanese children. 11354780 2001
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE Deletion/insertion polymorphism (D/I) of the angiotensin I converting enzyme gene, M235T polymorphism (T/M) of the angiotensinogen gene and A1166C polymorphism (C/A) of the angiotensin II type 1 receptor gene were determined in 274 Caucasian men with biopsy-proven IgAN (n = 86, 112, and 76 in stages 1, 2, and 3, respectively). 11053482 2000
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis
0.400 GeneticVariation disease BEFREE We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy. 9259580 1997