Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
AAA in male C57BL/6 J mice was induced by coadministration of angiotensin II (Ang II) and 3,4-benzopyrene (BaP).
|
30614051 |
2019 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
|
30850299 |
2019 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Murine BM-MSCs, MSCs-CM or control medium were intravenously administrated into AngII-induced AA in apoE<sup>-/-</sup> mice.
|
31583844 |
2019 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In an angiotensin II (Ang II)-induced mouse aortic aneurysm (AA) model, PTENP1 overexpression potentiated aortic SMC apoptosis, exacerbated aneurysm formation.
|
31235554 |
2019 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiotensin II (Ang II) infusion promotes the development of aortic aneurysms and accelerates atherosclerosis in ApoE<sup>-/-</sup> mice.
|
30048944 |
2018 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
To examine the role of SmgGDS in TAA formation, we used an angiotensin II (1000 ng·min<sup>-1</sup>·kg<sup>-1</sup>, 4 weeks)-induced TAA model.
|
29921611 |
2018 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
More importantly, adipocyte-specific PDGF-D transgenic mice are more susceptible to AA formation after AngII infusion accompanied by exaggerated adventitial inflammatory and fibrotic responses.
|
29794241 |
2018 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice.
|
28364044 |
2017 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of GFP was localized to macrophages in atherosclerotic plaques and in angiotensin II-induced aortic aneurysms and correlated with galectin 3 and mCD68 expression.
|
27908893 |
2017 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, the infusion of angiotensin II (Ang II) in the apolipoprotein E-deficient mice (apoE-/-) and low density lipoprotein receptor knockout mice (LDLR-/-) to induce aortic aneurysm has been extensively used in the field.
|
28500602 |
2017 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
XBP1u, but not XBP1s, was markedly repressed in the aorta during the early onset of aortic aneurysm in both angiotensin II-infused apolipoprotein E knockout (ApoE<sup>-/-</sup>) and CaPO<sub>4</sub> (calcium phosphate)-induced C57BL/6J murine models, in parallel with a decrease in smooth muscle cell contractile apparatus proteins.
|
29089350 |
2017 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parenteral administration of enoxaparin (FXa/IIa inhibitor) and fondaparinux (FXa inhibitor) over 14 days reduced to severity of aortic aneurysm and atherosclerosis in AngII-infused ApoE<sup>-/-</sup> mice.
|
28220880 |
2017 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis.
|
28062506 |
2017 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
<i>Arhgap18</i> global knockout (<i>Arhgap18</i><sup>-/</sup><sup>-</sup>) mice exhibited a highly synthetic, proteolytic, and proinflammatory smooth muscle phenotype under basal conditions and when challenged with angiotensin II, developed TAA with increased frequency and severity compared with littermate controls.
|
28701309 |
2017 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-2 attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in apolipoprotein E-deficient mice.
|
27767064 |
2016 |
Aortic Aneurysm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After infusion of angiotensin II at 1000 ng/kg per minute, 73% of Pparg(C/-) mice developed atypical suprarenal aortic aneurysms: superior mesenteric arteries were dilated with extensive collagen deposition in adventitia and infiltrations of inflammatory cells.
|
27045031 |
2016 |
Aortic Aneurysm
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
|
25378412 |
2015 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
In early atherosclerotic lesions, Rgs1 regulates macrophage accumulation and is required for the formation and rupture of Angiotensin II-induced aortic aneurysms, through effects on leukocyte retention.
|
25782711 |
2015 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, the combination of local periaortic leptin and systemic angiotensin II administration augmented medial MMP-9 synthesis and aortic aneurysm size.
|
23220275 |
2013 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation.
|
23967318 |
2013 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms.
|
22211965 |
2011 |
Aortic Aneurysm
|
0.400 |
Biomarker
|
disease |
CTD_human |
Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice.
|
21925196 |
2011 |