AGT, angiotensinogen, 183

N. diseases: 765; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma
0.070 Biomarker disease BEFREE Moreover, as APA overexpresses GPER this mechanism could contribute to the aldosterone excess that occurs in primary aldosteronism in a seemingly autonomous fashion from angiotensin II. 31125081 2019
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma
0.070 Biomarker disease BEFREE In order to clarify the pathophysiological roles of adrenal RAS in aldosterone-producing adenoma (APA), we studied the expressions of the messenger RNAs (mRNAs) of renin, angiotensinogen, type 1 (AT1R) and type 2 angiotensin II receptor (AT2R), CYP11B1 (11 beta-hydroxylase gene) and CYP11B2 (aldosterone synthase gene) in 8 patients with angiotensin II-responsive (ATII-R) APA and compared them with the expressions of the same mRNAs in 8 patients with angiotensin II-unresponsive (ATII-U) APA. 16715648 2006
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma
0.070 GeneticVariation disease BEFREE Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma. 9024263 1997
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma
0.070 AlteredExpression disease BEFREE Binding and gene expression studies have shown that AngII receptors are abundantly expressed in aldosterone-producing adenoma (APA).6. 21143284 1996
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma
0.070 Biomarker disease BEFREE The different responses of plasma aldosterone to ACTH and angiotensin II in aldosterone-producing adenoma (APA) is thought to be due to the various cellular compositions of the tumors. 7883831 1995
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma
0.070 Biomarker disease BEFREE We examined the possible association between restriction fragment length polymorphisms in the atrial natriuretic peptide (ANP) gene and responsiveness of aldosterone to angiotensin II in 59 patients with primary aldosteronism due to aldosterone-producing adenoma (APA). 7980610 1994
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma
0.070 Biomarker disease BEFREE We have described a new variety of aldosterone-producing adenoma which is responsive to angiotensin II (AII-responsive APA), consists of at least 20% zona glomerulosa-like cells, and does not make "hybrid steroids" in excess. 1352575 1992