Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature.
|
31836539 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
This study measured stimulus-evoked brain tissue oxygenation changes in a mouse model of Alzheimer disease (AD) and further explored the influence of exercise and angiotensin II-induced hypertension on these changes. in vivo two-photon phosphorescence lifetime microscopy was used to investigate local changes in brain tissue oxygenation following whisker stimulation.
|
31726177 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production.
|
31655853 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
During type 2 diabetes (T2D) and hypertension there is stimulation of renal proximal tubule angiotensinogen (AGT), but whether urinary excretion of AGT (uAGT) is an indicator of glomerular damage or intrarenal RAS activation is unclear.
|
31761419 |
2020 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of Brain Gα12 attenuates Angiotensin II Dependent Hypertension.
|
31677381 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To address this, TGR(mREN2)27 rats (a model of angiotensin II-dependent hypertension) were made diabetic for 12 weeks and treated with vehicle (n = 10), valsartan (ARB; n = 7) or sacubitril/valsartan (ARNI; n = 8) for the final 3 weeks.
|
31790054 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
However, the role of ICAM-1 in angiotensin II (Ang II)-induced hypertension development remains unknown.
|
31527830 |
2020 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Female rats harboring the human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype with hypertension and albuminuria during pregnancy when mated with male rats bearing the human renin gene [TGR(hRen)L10J] but behave physiologically normal before and after pregnancy.
|
31786987 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Utilizing our genetic mouse model of inducible renal lymphangiogenesis, we demonstrated that greatly augmenting renal lymphatic density prior to angiotensin II infusion prevented the development of hypertension in male and female mice and this was associated with a reduction in renal CD11c+F4/80- monocytes.
|
31429865 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Renal proximal tubular angiotensinogen (AGT) is increased by hyperglycemia (HG) in diabetes mellitus, which augments intrarenal angiotensin II formation, contributing to the development of hypertension and kidney injury.
|
31682172 |
2020 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Higher AGT levels in serum and urine in children with renal cysts may indicate the activation of the renin-angiotensin-aldosterone system, including its intrarenal part, even before the onset of hypertension.
|
31379247 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We generated a <i>Gstm1</i> knockout mouse line to study its role in a CKD model (involving subtotal nephrectomy) and a hypertension model (induced by angiotensin II).
|
31727850 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Blockade of Angiotensin-Converting Enzyme or TNF-α Reverses Maternal High Fat Diet-Induced Sensitization of Angiotensin II Hypertension in Male Rat Offspring.
|
31746626 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Treatment with the cathepsin L inhibitor Z-FF-FMK or the genetic deletion of cathepsin L significantly attenuated angiotensin II-induced hypertension, arterial remodeling, cathepsin L activation and MEK phosphorylation.
|
31668507 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II receptor blockers (ARBs) are recommended for treating patients with hypertension.
|
30964905 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
So, the aim of current study was to develop efficient low-cost method for genotyping of cardiovascular disease and hypertension associated polymorphisms of AGT (rs4762, rs5051) and CYP11B1 (rs6410).
|
30478747 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Our results show that NRP1 is required for full expression of DDAH1 in endothelial cells and that NRP1 contributes to protection from low-dose angiotensin II-induced increases in blood pressure.-Wang, Y., Wang, E., Zhang, Y., Madamsetty, V. S., Ji, B., Radisky, D. C., Grande, J. P., Misra, S., Mukhopadhyay, D. Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension.
|
30118322 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Finally, administration of neutralizing PDGF-C antibodies ameliorated angiotensin II-induced hypertension in healthy mice.
|
30827511 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II-induced hypertension increases the mutant frequency in rat kidney.
|
31098697 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We tested the hypothesis that SGLT2 inhibition with canagliflozin (CANA) prevents intrarenal AGT augmentation and ameliorates kidney injury and hypertension in T2DM.
|
30921791 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Telmisartan, an angiotensin II receptor blocker, has been widely used for hypertension.
|
30907023 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Therefore, ACE could be a potential therapeutic target in regulating the conversion of angiotensin I to angiotensin II and eventually controlling hypertension.
|
30875817 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.
|
30580687 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The insertion of mouse renin gene (Ren-2) into the genome of normotensive rats causes a spontaneous rise of blood pressure (BP), leading to an angiotensin II (Ang II)-dependent form of hypertension in transgenic (mRen-2)27 rats (TGR).
|
31037948 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
It was hypothesized that in vivo, functional deletion of Ca<sub>v</sub>3.1, but not Ca<sub>v</sub>3.2, protects mice against angiotensin II (ANG II)-induced hypertension.
|
31042060 |
2019 |