Renal Insufficiency
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We observe a positive correlation between miR-103a-3p levels and AngII-induced renal dysfunction. miR-103a-3p suppresses expression of the sucrose non-fermentable-related serine/threonine-protein kinase SNRK in glomerular endothelial cells, and glomeruli of HN patients and AngII-infused mice show reduced endothelial expression of SNRK.
|
31086184 |
2019 |
Renal Insufficiency
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A number of vasoactive mediators including proprotein convertase subtilisin-kexin type 9 (PCSK9), endothelin-1, nitric oxide, and angiotensin II have fundamental roles in the pathophysiology of atherosclerotic events; moreover, their levels are affected by dyslipidemia and oxidative stress due to renal dysfunction.
|
31641998 |
2019 |
Renal Insufficiency
|
0.400 |
Biomarker
|
disease |
BEFREE |
We evaluated the hypothesis that the development of renal dysfunction and congestive heart failure (CHF) caused by volume overload in rats with angiotensin II (ANG II)-dependent hypertension is associated with altered renal vascular responsiveness to ANG II and to epoxyeicosatrienoic acids (EETs).
|
31430751 |
2019 |
Renal Insufficiency
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Possibly, the development of renal dysfunction in the females, unlike in males, is associated with altered renal vascular responsiveness to angiotensin II (ANG II).
|
31505499 |
2019 |
Renal Insufficiency
|
0.400 |
Biomarker
|
disease |
BEFREE |
Results show that SGK1 inhibitor EMD638683 significantly reversed renal dysfunction and cardiac dysfunction in echocardiography as indicated by decreased blood urine nitrogen and serum creatinine in AngII-infused mice.
|
30524295 |
2018 |
Renal Insufficiency
|
0.400 |
Biomarker
|
disease |
BEFREE |
2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.
|
28416584 |
2017 |
Renal Insufficiency
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the augmented intrarenal AGT mRNA expression paralleled renal dysfunction in patients with diabetes.
|
24284398 |
2013 |
Renal Insufficiency
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed single nucleotide polymorphisms (SNPs) associated with cardiovascular pathophysiology (including AGT1R T573C, AGT1R A1166C, and AGT M235T) and presence of renal dysfunction (eGFR<60 ml/min/1.73 m2) or history of CHD.
|
19327134 |
2009 |
Renal Insufficiency
|
0.400 |
Biomarker
|
disease |
BEFREE |
A prospective population-based study of CKD risk was conducted among 3706 black individuals without severe renal dysfunction at baseline (serum creatinine > or =177 micromol/L [2.0 mg/dl] for men, > or =159 micromol/L [1.8 mg/dl] for women) to examine associations with AGT and AT1R.
|
16396964 |
2006 |
Renal Insufficiency
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, the angiotensinogen -235T allele was found to be related with steroid resistance, renal dysfunction and progression of ESRD in nephrotic syndrome.
|
16525944 |
2005 |
Renal Insufficiency
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently it was reported that polymorphism at -20 from adenine to cytosine in the angiotensinogen gene, increasing the level of this transcript, was associated with the progression of renal dysfunction in adult IgA nephropathy.
|
14648325 |
2004 |
Renal Insufficiency
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies.
|
12832734 |
2003 |
Renal Insufficiency
|
0.400 |
Biomarker
|
disease |
CTD_human |
Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.
|
9259580 |
1997 |