AGT, angiotensinogen, 183

N. diseases: 765; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 AlteredExpression disease BEFREE We observe a positive correlation between miR-103a-3p levels and AngII-induced renal dysfunction. miR-103a-3p suppresses expression of the sucrose non-fermentable-related serine/threonine-protein kinase SNRK in glomerular endothelial cells, and glomeruli of HN patients and AngII-infused mice show reduced endothelial expression of SNRK. 31086184 2019
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 AlteredExpression disease BEFREE A number of vasoactive mediators including proprotein convertase subtilisin-kexin type 9 (PCSK9), endothelin-1, nitric oxide, and angiotensin II have fundamental roles in the pathophysiology of atherosclerotic events; moreover, their levels are affected by dyslipidemia and oxidative stress due to renal dysfunction. 31641998 2019
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 Biomarker disease BEFREE We evaluated the hypothesis that the development of renal dysfunction and congestive heart failure (CHF) caused by volume overload in rats with angiotensin II (ANG II)-dependent hypertension is associated with altered renal vascular responsiveness to ANG II and to epoxyeicosatrienoic acids (EETs). 31430751 2019
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 GeneticVariation disease BEFREE Possibly, the development of renal dysfunction in the females, unlike in males, is associated with altered renal vascular responsiveness to angiotensin II (ANG II). 31505499 2019
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 Biomarker disease BEFREE Results show that SGK1 inhibitor EMD638683 significantly reversed renal dysfunction and cardiac dysfunction in echocardiography as indicated by decreased blood urine nitrogen and serum creatinine in AngII-infused mice. 30524295 2018
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 Biomarker disease BEFREE 2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice. 28416584 2017
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 AlteredExpression disease BEFREE Moreover, the augmented intrarenal AGT mRNA expression paralleled renal dysfunction in patients with diabetes. 24284398 2013
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 GeneticVariation disease BEFREE We analyzed single nucleotide polymorphisms (SNPs) associated with cardiovascular pathophysiology (including AGT1R T573C, AGT1R A1166C, and AGT M235T) and presence of renal dysfunction (eGFR<60 ml/min/1.73 m2) or history of CHD. 19327134 2009
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 Biomarker disease BEFREE A prospective population-based study of CKD risk was conducted among 3706 black individuals without severe renal dysfunction at baseline (serum creatinine > or =177 micromol/L [2.0 mg/dl] for men, > or =159 micromol/L [1.8 mg/dl] for women) to examine associations with AGT and AT1R. 16396964 2006
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 GeneticVariation disease BEFREE In this study, the angiotensinogen -235T allele was found to be related with steroid resistance, renal dysfunction and progression of ESRD in nephrotic syndrome. 16525944 2005
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 GeneticVariation disease BEFREE Recently it was reported that polymorphism at -20 from adenine to cytosine in the angiotensinogen gene, increasing the level of this transcript, was associated with the progression of renal dysfunction in adult IgA nephropathy. 14648325 2004
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 GeneticVariation disease BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734 2003
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency
0.400 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997