Allanson Pantzar McLeod syndrome
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Novel variants detected in AGT gene among patients with essential hypertension.
|
24452034 |
2015 |
Allanson Pantzar McLeod syndrome
|
0.710 |
GeneticVariation
|
disease |
BEFREE |
Renal function in angiotensinogen gene-mutated renal tubular dysgenesis with glomerular cysts.
|
25414114 |
2015 |
Allanson Pantzar McLeod syndrome
|
0.710 |
GermlineCausalMutation
|
disease |
ORPHANET |
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.
|
22095942 |
2012 |
Allanson Pantzar McLeod syndrome
|
0.710 |
Biomarker
|
disease |
CTD_human |
A case surviving for over a year of renal tubular dysgenesis with compound heterozygous angiotensinogen gene mutations.
|
17036344 |
2006 |
Allanson Pantzar McLeod syndrome
|
0.710 |
Biomarker
|
disease |
CTD_human |
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
|
16116425 |
2005 |
Allanson Pantzar McLeod syndrome
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
|
16116425 |
2005 |
Allanson Pantzar McLeod syndrome
|
0.710 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
|
16116425 |
2005 |
Allanson Pantzar McLeod syndrome
|
0.710 |
Biomarker
|
disease |
HPO |
|
|
|
Allanson Pantzar McLeod syndrome
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Allanson Pantzar McLeod syndrome
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature.
|
31836539 |
2020 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, the pathological involvement of Angiotensin-converting enzyme 1 (ACE1)/angiotensin II (Ang II)/angiotensin II type 1 (AT1) axis and beneficial ACE2/Ang (1-7)/Mas receptor axis also shows protective role via Gi βγ, during heart failure these receptors get desensitized or internalized due to increase in the activity of G-protein-coupled receptor kinase 2 (GRK2) and GRK5, responsible for phosphorylation of G-protein-mediated down regulatory signaling.
|
31785110 |
2020 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Substantial evidence suggests that heart failure (HF) may alter cardiac Ang-(1-12) expression and activity; this novel Ang-(1-12)/chymase axis may be the main source for angiotensin-II deleterious actions in HF.
|
31521437 |
2020 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature.
|
31836539 |
2020 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Substantial evidence suggests that heart failure (HF) may alter cardiac Ang-(1-12) expression and activity; this novel Ang-(1-12)/chymase axis may be the main source for angiotensin-II deleterious actions in HF.
|
31521437 |
2020 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, the pathological involvement of Angiotensin-converting enzyme 1 (ACE1)/angiotensin II (Ang II)/angiotensin II type 1 (AT1) axis and beneficial ACE2/Ang (1-7)/Mas receptor axis also shows protective role via Gi βγ, during heart failure these receptors get desensitized or internalized due to increase in the activity of G-protein-coupled receptor kinase 2 (GRK2) and GRK5, responsible for phosphorylation of G-protein-mediated down regulatory signaling.
|
31785110 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature.
|
31836539 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
This study measured stimulus-evoked brain tissue oxygenation changes in a mouse model of Alzheimer disease (AD) and further explored the influence of exercise and angiotensin II-induced hypertension on these changes. in vivo two-photon phosphorescence lifetime microscopy was used to investigate local changes in brain tissue oxygenation following whisker stimulation.
|
31726177 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production.
|
31655853 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
During type 2 diabetes (T2D) and hypertension there is stimulation of renal proximal tubule angiotensinogen (AGT), but whether urinary excretion of AGT (uAGT) is an indicator of glomerular damage or intrarenal RAS activation is unclear.
|
31761419 |
2020 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of Brain Gα12 attenuates Angiotensin II Dependent Hypertension.
|
31677381 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To address this, TGR(mREN2)27 rats (a model of angiotensin II-dependent hypertension) were made diabetic for 12 weeks and treated with vehicle (n = 10), valsartan (ARB; n = 7) or sacubitril/valsartan (ARNI; n = 8) for the final 3 weeks.
|
31790054 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
However, the role of ICAM-1 in angiotensin II (Ang II)-induced hypertension development remains unknown.
|
31527830 |
2020 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Female rats harboring the human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype with hypertension and albuminuria during pregnancy when mated with male rats bearing the human renin gene [TGR(hRen)L10J] but behave physiologically normal before and after pregnancy.
|
31786987 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Utilizing our genetic mouse model of inducible renal lymphangiogenesis, we demonstrated that greatly augmenting renal lymphatic density prior to angiotensin II infusion prevented the development of hypertension in male and female mice and this was associated with a reduction in renal CD11c+F4/80- monocytes.
|
31429865 |
2020 |