Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Blockade of endogenous Angiotensin II type I receptor agonistic autoantibody activity improves mitochondria reactive oxygen species and hypertension in a rat model of Preeclampsia.
|
31721604 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We hypothesized that AT1R couple with Gα12 and/or Gαq to produce sympatho-excitation and increase BP and downregulation of these Gα subunit proteins will attenuate Ang II dependent hypertension.
|
31677381 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We previously reported that hypertension in female growth-restricted offspring that is associated with early reproductive senescence and a shift in the testosterone-to-estradiol ratio at 12 months of age is abolished by AR (androgen receptor) blockade in conjunction with downregulation of renal AT1aR (angiotensin type 1a receptor) mRNA expression.
|
31378101 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Our data indicate an essential and systemic role for TG2 in bridging inflammation to hypertension via its posttranslational modifications stabilizing AT1 receptor and sensitizing Ang II.
|
30715101 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Telmisartan, widely prescribed for the treatment of hypertension, has an anti-inflammatory property in addition to being an angiotensin II type 1 receptor antagonist.
|
31330445 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension.
|
30311805 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Findings support that FPH is associated with a vascular hyper-sympathetic activation, involving a tonic facilitation of prejunctional AT1 receptors by endogenous Ang II, which can justify, at least in part, the development of hypertension.
|
30326265 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Conclusions Ang II-induced hypertension is caused by AGTR1 overexpression in the kidneys via the upregulation of BubR1 and Nox4.
|
31787052 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT<sub>1</sub>R) blockers, current therapies for hypertension and related cardiovascular diseases are still inadequate.
|
31537750 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The results suggest that parental hypertension results in elevated BP and autonomic dysfunction in adult male offspring through activation of AT1R pathway and inhibition of endogenous H<sub>2</sub>S production in the brain.
|
31607943 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We investigated whether Ang II, via induction of AT1R and μ-opioid receptor (μOR) dimerization in the nucleus tractus solitarius (NTS), leads to progressive hypertension.
|
31755934 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Losartan, an angiotensin II (Ang II) receptor blocker acting on the Ang II type-1 receptor (AT1R) subtype, is a prescription drug for treating hypertension.
|
30991833 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
AT1R-Abs (autoantibodies to the angiotensin II type 1 receptor) have been reported in patients with disorders associated with hypertension.
|
31476909 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Losartan, an angiotensin II type 1 receptor (AT1R) antagonist widely used to treat hypertension, has been reported to have analgesic effects in several pain models.
|
31037647 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Telmisartan (TEL), an angiotensin II type I receptor blocker and PPARγ partial agonist, has been used for to treat hypertension.
|
31606379 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.
|
30842613 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA).
|
31805646 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypertension is also associated with B cell activation and production of autoantibodies (anti-Hsp70, anti-Hsp65, anti-Hsp60, anti-AT1R, anti-α1AR, and anti-β1AR).
|
31321561 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Nonalcoholic fatty liver disease and hypertension are closely related but there has been little genetic evidence to link them.In this issue, Musso et al. provide evidence that a common variant in AGTR1 (A1166C) is associated with both incident hypertension and nonalcoholic fatty liver disease, as well as nonalcoholic steatohepatitis, fibrosis, dyslipidemia, and insulin resistance.
|
30951517 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Although exogenous angiotensin II (AngII) can increase NMDAR activity in the PVN, whether endogenous AT1 receptor-protein kinase C (PKC) activity mediates the augmented NMDAR activity of PVN presympathetic neurons in hypertension is unclear.
|
31241170 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
AGTR1 A1166C polymorphism predicted 9.8-year incident NAFLD (odds ratio: 1.67, 95% CI: 1.26-2.21) and hypertension (odds ratio: 1.49, 95% CI: 1.12-2.63) and 9-year increase in cardiovascular disease risk and endothelial dysfunction markers.
|
30920415 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Thus, we concluded that AT1 pathway plays a role in pulmonary vascular dysfunction by increasing oxidative stress and reducing NO bioavailability, thereby contributing to vascular remodeling and pulmonary hypertension of iron-overload.
|
29990562 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Since Hap-I of the human AT1R gene is associated with hypertension in Caucasians, we generated transgenic (TG) mice with Hap-I and Hap-II and studied the physiological significance of high fat diet (HFD) on haplotype specific gene expression.
|
29036458 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
AT1R antibody was associated with renal allograft loss (odds ratio of 13.1 [95% confidence interval 1.48-1728]), the presence of glomerulitis or arteritis, and significantly higher TNF-α, IL-1β, and IL-8 levels, but not rejection or hypertension.
|
28927645 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To explore the roles of glutamate acid decarboxylase 65 (GAD65) and angiotensin II type 1 receptor (AT<sub>1</sub>R) in the action of renal sympathetic denervation (RSD) on obesity-induced hypertension in canines.
|
29172730 |
2018 |