Allanson Pantzar McLeod syndrome
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension.
|
25603901 |
2015 |
Allanson Pantzar McLeod syndrome
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.
|
22095942 |
2012 |
Allanson Pantzar McLeod syndrome
|
0.700 |
Biomarker
|
disease |
CTD_human |
We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1.
|
16116425 |
2005 |
Allanson Pantzar McLeod syndrome
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1.
|
16116425 |
2005 |
Allanson Pantzar McLeod syndrome
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1.
|
16116425 |
2005 |
Allanson Pantzar McLeod syndrome
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Allanson Pantzar McLeod syndrome
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Allanson Pantzar McLeod syndrome
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Blockade of endogenous Angiotensin II type I receptor agonistic autoantibody activity improves mitochondria reactive oxygen species and hypertension in a rat model of Preeclampsia.
|
31721604 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We hypothesized that AT1R couple with Gα12 and/or Gαq to produce sympatho-excitation and increase BP and downregulation of these Gα subunit proteins will attenuate Ang II dependent hypertension.
|
31677381 |
2020 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The target of the current study was to examine the possible cardioprotective effect of telmisartan (Tel), an angiotensin II type 1 receptor (AT1R) blocker, compared with that of captopril (Cap), an angiotensin converting enzyme (ACE) inhibitor, in ameliorating PRG-induced HF in rats by assessing morphometric, echocardiographic and histopathological parameters.
|
31629013 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this paper, we review the recent advances in the field of β-arrestin signaling of the AT1R, emphasizing its role in cardiovascular regulation and heart failure.
|
31447777 |
2019 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis showed significant associations between rs5186 in AGTR1 and increased rates by 25-34% for the primary endpoint (composite of death or nonfatal myocardial infarction, hospitalization for unstable angina, heart failure or peripheral vascular event), all-cause mortality, cardiovascular mortality and heart failure; all P < 0.001.
|
29982608 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this paper, we review the recent advances in the field of β-arrestin signaling of the AT1R, emphasizing its role in cardiovascular regulation and heart failure.
|
31447777 |
2019 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis showed significant associations between rs5186 in AGTR1 and increased rates by 25-34% for the primary endpoint (composite of death or nonfatal myocardial infarction, hospitalization for unstable angina, heart failure or peripheral vascular event), all-cause mortality, cardiovascular mortality and heart failure; all P < 0.001.
|
29982608 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The target of the current study was to examine the possible cardioprotective effect of telmisartan (Tel), an angiotensin II type 1 receptor (AT1R) blocker, compared with that of captopril (Cap), an angiotensin converting enzyme (ACE) inhibitor, in ameliorating PRG-induced HF in rats by assessing morphometric, echocardiographic and histopathological parameters.
|
31629013 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We previously reported that hypertension in female growth-restricted offspring that is associated with early reproductive senescence and a shift in the testosterone-to-estradiol ratio at 12 months of age is abolished by AR (androgen receptor) blockade in conjunction with downregulation of renal AT1aR (angiotensin type 1a receptor) mRNA expression.
|
31378101 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Our data indicate an essential and systemic role for TG2 in bridging inflammation to hypertension via its posttranslational modifications stabilizing AT1 receptor and sensitizing Ang II.
|
30715101 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Telmisartan, widely prescribed for the treatment of hypertension, has an anti-inflammatory property in addition to being an angiotensin II type 1 receptor antagonist.
|
31330445 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension.
|
30311805 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Findings support that FPH is associated with a vascular hyper-sympathetic activation, involving a tonic facilitation of prejunctional AT1 receptors by endogenous Ang II, which can justify, at least in part, the development of hypertension.
|
30326265 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Conclusions Ang II-induced hypertension is caused by AGTR1 overexpression in the kidneys via the upregulation of BubR1 and Nox4.
|
31787052 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT<sub>1</sub>R) blockers, current therapies for hypertension and related cardiovascular diseases are still inadequate.
|
31537750 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The results suggest that parental hypertension results in elevated BP and autonomic dysfunction in adult male offspring through activation of AT1R pathway and inhibition of endogenous H<sub>2</sub>S production in the brain.
|
31607943 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We investigated whether Ang II, via induction of AT1R and μ-opioid receptor (μOR) dimerization in the nucleus tractus solitarius (NTS), leads to progressive hypertension.
|
31755934 |
2019 |