EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease. 29545351 2018
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Endothelin-1 (ET-1) is a potent vasoconstrictor that is released during VOEs and is correlated with pain history. 25486928 2015
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype CTD_human Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats. 19429182 2009
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Recent studies in our laboratory have revealed that low-level blast exposure increased expression of transient receptor potential vanilloid 1 (TRPV1) and endothelin-1 (ET-1), proteins well characterized for their role in mediating pain transmission, in the cornea. 28797041 2017
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE The present study investigated whether endothelin-1 acts via ET<sub>A</sub> or ET<sub>B</sub> receptors to mediate superoxide anion-induced pain and inflammation. 27701898 2017
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype CTD_human Our results suggested that TRPA1 is involved in ET-1-induced spontaneous pain-like behavior in mice. 20042899 2010
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Over the years various treatment modalities have been tried and tested to improve the pain management including the use of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, bisphosphonates, tricyclic antidepressants, corticosteroids, growth factors and signaling molecules, ET-1 receptor antagonists, radiotherapy as well as surgical management. 30443456 2018
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE The present study demonstrated (1) the presence and the function of the BK system in endometriosis, (2) activation of BKR induced endothelin-1 in endometriotic lesion and (3) blocking endothelin-1 was effective to decrease pain. 29034546 2018
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent cutaneous pain. 29947541 2018
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Pharmacological targeting of TRPA1 and ET<sub>A</sub>R-PKA pathway may provide effective strategies to alleviate pain conditions associated with ET-1. 30990108 2020
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE These findings support the suggestion that ET-1 and ET-A receptors contribute to the severity of carcinoma-induced soft tissue cancer pain. 16807013 2007
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE Elevated levels of plasma TNF-α, IL-8, and ET-1 further establish the chronic inflammatory state in SCA and equally affirm their significant contribution, not only to pathogenesis but also to the severity of pain in SCA. 29531654 2018
CUI: C0030193
Disease: Pain
Pain
0.400 AlteredExpression phenotype BEFREE Endothelin-1 is upregulated in oral mucosal inflammation, although it has not been shown to induce pain in oral ulcers. 29518348 2018
CUI: C0030193
Disease: Pain
Pain
0.400 Biomarker phenotype BEFREE This review focused on how transient receptor potential vanilloid 1, endothelin-1/endothelin type A receptor, and cannabinoid receptors contributed to the pathophysiology of SCD-associated pain. 31505241 2019
CUI: C0030193
Disease: Pain
Pain
0.400 AlteredExpression phenotype BEFREE The present study assessed the effects of ETBR activation and the role of endogenous opioid analgesia in carcinoma pain using an orthotopic cancer pain mouse model. mRNA expression analysis showed that ET-1 was nearly doubled while ETBR was significantly down-regulated in a human oral SCC cell line compared to normal oral keratinocytes (NOK). 20206445 2010