Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.380 AlteredExpression disease BEFREE HRH1 was differentially expressed in adults with asthma vs. controls (p = 0.04), and EDN1 was differentially expressed in children with asthma vs. controls 12-18 years old (p = 0.03). 23448392 2013
CUI: C0004096
Disease: Asthma
Asthma
0.380 AlteredExpression disease BEFREE Augmented epithelial endothelin-1 expression in refractory asthma. 17996929 2008
CUI: C0004096
Disease: Asthma
Asthma
0.380 Biomarker disease LHGDN Increased endothelin 1 synthesis by the bronchial epithelium characterizes severe refractory asthma and correlates with airway remodeling and airflow obstruction. 17996929 2008
CUI: C0004096
Disease: Asthma
Asthma
0.380 GeneticVariation disease LHGDN Polymorphisms in EDN1 are associated with asthma in two populations. 17960156 2008
CUI: C0004096
Disease: Asthma
Asthma
0.380 GeneticVariation disease BEFREE Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations. 17960156 2008
CUI: C0004096
Disease: Asthma
Asthma
0.380 Biomarker disease CTD_human MZC is the effective part of MZ and the anti-asthmatic mechanisms ware related to its significant reduction in contents of ET-1, NO, EOS and the damage of lung tissue possibly. 16981460 2007
CUI: C0004096
Disease: Asthma
Asthma
0.380 Biomarker disease BEFREE Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. 17470272 2007
CUI: C0004096
Disease: Asthma
Asthma
0.380 Biomarker disease BEFREE Plasma endothelin-1 immunoreactivity in asthmatic children. 11991554 2002
CUI: C0004096
Disease: Asthma
Asthma
0.380 GeneticVariation disease BEFREE These are the IL10 -592C>A SNP in the interleukin 10 gene (p=0.036 for eosinophil cell counts), the 4124T>C SNP in EDN1 (p=0.044 for asthma), the 3391C>T SNP in NOS1 with eosinophil cell counts (p=0.0086), and the 5266C>T polymorphism, also in the NOS1 gene, for high IgE levels (p=0.022). 11668616 2002
CUI: C0004096
Disease: Asthma
Asthma
0.380 GeneticVariation disease BEFREE We tested a hypothesis that asthma or other atopic diseases are associated with insertion/deletion ACE, M235T angiotensinogen, and TaqI ET-1 gene polymorphisms. 10200023 1999
CUI: C0004096
Disease: Asthma
Asthma
0.380 AlteredExpression disease BEFREE Furthermore, erythromycin and clarithromycin inhibited ET-1 expression in bronchoepithelial cells from patients with chronic, stable asthma. 9701415 1998