Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, information regarding the roles of ET-1 and arginase, as well as the interactions between the two in human atherosclerosis, is scarce.
|
31606133 |
2020 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The vasoactive peptide, endothelin-1 (ET-1), plays a key role in the development of atherosclerosis.
|
30809816 |
2019 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ET-1 receptor antagonists (ERAs) are used for the treatment of PAH but less is known about whether ERAs are beneficial in atherosclerosis.
|
29261014 |
2019 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, after the occurrence of atherosclerosis, we found the carotid IMT is negatively correlated with endothelial-dependent FMD, as well as levels of VEGF and ET-1, whereas shows positive correlation with the vasodilative factor NO.
|
31006671 |
2019 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation, and atherosclerosis.
|
29654172 |
2018 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All‑trans retinoic acid reduces endothelin‑1 expression and increases endothelial nitric oxide synthase phosphorylation in rabbits with atherosclerosis.
|
29207193 |
2018 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOD and MDA in the AS + nitrate ester group decreased gradually with time, but •O2-, NO- and ET-1 levels increased (p < 0.05).
|
29565509 |
2018 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objectives of this study were: a) to determine the relative contribution of cyclooxygenases (Cox-1 and Cox-2), thromboxane A2 (TXA2) and endothelin-1 (ET-1) to enhancing vascular hyperresponsiveness in this model of atherosclerosis and b) to investigate the beneficial effects of the phosphodiesterase 5 inhibitor sildenafil on this endothelial dysfunction.
|
29216624 |
2017 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both endothelin-1 and oxidative stress have important roles in the development of cardiovascular diseases such as hypertension and atherosclerosis.
|
27682654 |
2017 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have reported important roles of endothelin-1 (ET-1) and angiotensin II (Ang II) in the pathogenesis of atherosclerosis.
|
24877885 |
2015 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice.
|
23887640 |
2013 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 (ET-1) promotes atherosclerosis.
|
22321643 |
2012 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ECW also substantially inhibited the development of atherosclerosis, possibly by inhibiting ET-1, cell adhesion molecules, and lesion formation, suggesting a vascular protective role for this herb in the treatment and prevention of atherosclerotic vascular disease.
|
22082065 |
2012 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Regulator of G-protein signaling 2 (RGS2) is a key molecule in signal pathways of vasoactive peptides, such as angiotensin II and endothelin 1, and is believed to have an important role in the pathophysiology of atherosclerosis.
|
21451528 |
2011 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to analyse the role of the ET-1 gene (EDN1) in the risk for atherosclerosis/myocardial infarction (MI) in a population with smoking as the prevalent risk factor.
|
19672034 |
2009 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although ET-1 is thought to play an important role in the development of atherosclerosis, it remains unclear whether polymorphisms of ET-1 family genes, including the ET-1 gene (EDN1), EDNRA, EDNRB and the genes for endothelin converting enzymes 1 and 2 (ECE1 and ECE2), are associated with the progression of atherosclerosis.
|
17525706 |
2007 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
We postulate that the ET-1 is active participant in cytokine- and sCAM-induced inflammatory repsonse at atherosclerosis.
|
15838299 |
2004 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epigenetic topography of lymphocyte nuclei and endothelin-1 at atherosclerosis.
|
15838357 |
2004 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Epigenetic topography of lymphocyte nuclei and endothelin-1 at atherosclerosis.
|
15838357 |
2004 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Many of the up-regulated genes-including the hyaluron receptor CD44, vasoconstrictor endothelin-1, smooth muscle growth factor heparin-binding EGF-like growth factor, and fatty acid binding protein-4-had been previously described as linked to the development of atherosclerosis and other chronic inflammatory diseases.
|
14593587 |
2003 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 (ET-1) may be involved in the development and progression of atherosclerosis.
|
12193044 |
2002 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: implications for atherosclerosis.
|
11162610 |
2001 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because of the potential role of ET-1 in vascular disorders such as hypertension and atherosclerosis, we investigated the regulation of ET-1 expression by PPAR activators.
|
10473669 |
1999 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings are consistent with the contention that endothelial damage occurs in most patients with atherosclerosis and/or hypertension and that ET-1 is synthesized in VSMCs of these patients.
|
10069781 |
1999 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results support the hypothesis that expression of ET-1, at sites containing atheromatous disease, may be involved in the development of atherosclerosis.
|
8800491 |
1996 |