EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Endothelin 1 Is Associated with Heart Failure Hospitalization and Long-Term Mortality in Patients with Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension. 31514181 2020
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Endothelin-1 has been studied as a predictor of and prognostic marker in coronary artery disease, myocardial infarction, and heart failure. 30765295 2020
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation disease BEFREE Lower risk for heart failure with higher ET1 levels could not be clearly shown in a model including health behaviors. 31515065 2020
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Therefore, targeting the EC-Foxp1-TGF-β1-endothelin-1 pathway might provide a future novel therapy for heart failure. 31177814 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE These results revealed that TCDD directly induces cardiotoxicity in the postnatal period represented by progressive hypertrophy in which ANP, β-MHC, and ET-1 have potentials to mediate the cardiac hypertrophy and heart failure. 31270306 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Serum concentration of big endothelin-1 (ET-1) has prognostic significance in heart failure. 29913121 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Concentrations of ET-1 above the median were associated with shorter time to incident HF, MI, cardiovascular mortality, all-cause mortality, and the composite of incident HF/MI/cardiovascular mortality (all log-rank <i>P</i> < 0.001). 30213784 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE The actions of ET-1 are evident during normal adaptive physiological responses and increased under pathophysiological conditions, such as following myocardial infarction and during heart failure, where ET-1 levels are elevated. 29470978 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Endothelin-1 (ET-1) and its receptor endothelin A receptor (ET[Formula: see text] have been shown to be upregulated in a high glucose environment, which increase the incidence of diabetes-related heart failure. 30149760 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. 29872396 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Elevated ET-1 was associated with worse HF, lower right ventricular function, higher pulmonary pressure, and higher left atrial volume index despite similar left ventricular function. 28398455 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE Our meta-analysis provided evidence that increased plasma levels of ET-1, big ET-1, and CT-proET-1 were associated with poor prognosis or mortality for HF populations. 29390406 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Finally, elevated natriuretic peptides, ST2, endothelin-1, mid-regional-pro-adrenomedullin, copeptin, and galectin-3 have all been well validated to predict death and heart failure following a MI and provide risk stratification information for heart failure. 28491088 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE Our study shows that fenofibrate may protect against ET-1-induced cardiomyocyte hypertrophy and enhanced adiponectin expression through modulation of PPARα expression in vitro and limitation of daunorubicin cardiotoxicity in vivo, suggesting a novel mechanistic insight into the role of PPARα and adiponectin in cardiac hypertrophy and heart failure. 27629528 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE The increased EDN1 production may lead to constriction of coronary arteries, reducing coronary blood flow which may in turn increase the load on left ventricle, impairing contractility of the heart resulting in a DCM phenotype, an end stage of heart failure. 25042451 2014
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Elevated atrial ET-1 content is associated with increased LA size, AF rhythm, hypertension, and heart failure. 20495015 2010
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation disease BEFREE A common endothelin-1 gene haplotype may be a pharmacogenetic predictor of a favorable clinical response to beta-blocker therapy in heart failure patients. 18953265 2009
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Despite this baseline cytosolic HDAC5 shift, endothelin-1 produced more rapid HDAC5-GFP nuclear export in HF versus control myocytes. 18218981 2008
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease CTD_human The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT). 16762801 2006
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Experimental studies and clinical trials have demonstrated that ET-1 plays a major role in normal cardiovascular homeostasis and in the functional and structural changes observed in arterial and pulmonary hypertension, glomerulosclerosis, atherosclerosis, and heart failure. 16855133 2006
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease LHGDN Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients. 16095497 2005
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE These are the first data to demonstrate that cardiac overexpression of ET-1 is sufficient to cause increased expression of inflammatory cytokines and an inflammatory cardiomyopathy leading to heart failure and death. 14718401 2004
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Endothelin-1 (ET-1) is considered to be involved in the development and progression of heart failure. 12193094 2002
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE Elevation of ventricular filling pressure up-regulates RLX expression and the hormone acts as a potent inhibitor of endothelin 1, the most powerful vasoconstrictor in heart failure. 11641245 2001