Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Endothelin 1 Is Associated with Heart Failure Hospitalization and Long-Term Mortality in Patients with Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension.
|
31514181 |
2020 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 has been studied as a predictor of and prognostic marker in coronary artery disease, myocardial infarction, and heart failure.
|
30765295 |
2020 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lower risk for heart failure with higher ET1 levels could not be clearly shown in a model including health behaviors.
|
31515065 |
2020 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, targeting the EC-Foxp1-TGF-β1-endothelin-1 pathway might provide a future novel therapy for heart failure.
|
31177814 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results revealed that TCDD directly induces cardiotoxicity in the postnatal period represented by progressive hypertrophy in which ANP, β-MHC, and ET-1 have potentials to mediate the cardiac hypertrophy and heart failure.
|
31270306 |
2019 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The actions of ET-1 are evident during normal adaptive physiological responses and increased under pathophysiological conditions, such as following myocardial infarction and during heart failure, where ET-1 levels are elevated.
|
29470978 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Concentrations of ET-1 above the median were associated with shorter time to incident HF, MI, cardiovascular mortality, all-cause mortality, and the composite of incident HF/MI/cardiovascular mortality (all log-rank <i>P</i> < 0.001).
|
30213784 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure.
|
29872396 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Endothelin-1 (ET-1) and its receptor endothelin A receptor (ET[Formula: see text] have been shown to be upregulated in a high glucose environment, which increase the incidence of diabetes-related heart failure.
|
30149760 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum concentration of big endothelin-1 (ET-1) has prognostic significance in heart failure.
|
29913121 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Synthesis of these peptides correlated with ET-1, and plasma ELDP and CT-proET-1 were elevated in patients with chronic heart failure.
|
28694457 |
2017 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our study shows that fenofibrate may protect against ET-1-induced cardiomyocyte hypertrophy and enhanced adiponectin expression through modulation of PPARα expression in vitro and limitation of daunorubicin cardiotoxicity in vivo, suggesting a novel mechanistic insight into the role of PPARα and adiponectin in cardiac hypertrophy and heart failure.
|
27629528 |
2017 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, elevated natriuretic peptides, ST2, endothelin-1, mid-regional-pro-adrenomedullin, copeptin, and galectin-3 have all been well validated to predict death and heart failure following a MI and provide risk stratification information for heart failure.
|
28491088 |
2017 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Elevated ET-1 was associated with worse HF, lower right ventricular function, higher pulmonary pressure, and higher left atrial volume index despite similar left ventricular function.
|
28398455 |
2017 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our meta-analysis provided evidence that increased plasma levels of ET-1, big ET-1, and CT-proET-1 were associated with poor prognosis or mortality for HF populations.
|
29390406 |
2017 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The increased EDN1 production may lead to constriction of coronary arteries, reducing coronary blood flow which may in turn increase the load on left ventricle, impairing contractility of the heart resulting in a DCM phenotype, an end stage of heart failure.
|
25042451 |
2014 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Elevated atrial ET-1 content is associated with increased LA size, AF rhythm, hypertension, and heart failure.
|
20495015 |
2010 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A common endothelin-1 gene haplotype may be a pharmacogenetic predictor of a favorable clinical response to beta-blocker therapy in heart failure patients.
|
18953265 |
2009 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Despite this baseline cytosolic HDAC5 shift, endothelin-1 produced more rapid HDAC5-GFP nuclear export in HF versus control myocytes.
|
18218981 |
2008 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the frequency of endothelin-1 Lys198Asn polymorphism was investigated with respect to the prevalence of several actual or historical endorgan damages (renal disorder, coronary artery disease, vascular events, vascular damage, and congestive heart failure) in hypertensive patients.
|
18923236 |
2008 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The second objective is to find an association between polymorphisms G8002A and -3A/4A EDN-1 with diabetes mellitus (DM), peripheral artery disease (PAD) and myocardial infarction (MI) in patients with chronic heart failure (CHF).
|
18442814 |
2008 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Experimental studies and clinical trials have demonstrated that ET-1 plays a major role in normal cardiovascular homeostasis and in the functional and structural changes observed in arterial and pulmonary hypertension, glomerulosclerosis, atherosclerosis, and heart failure.
|
16855133 |
2006 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT).
|
16762801 |
2006 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
The effects of atorvastatin (10 mg) on systemic inflammation in heart failure.
|
16360360 |
2005 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These are the first data to demonstrate that cardiac overexpression of ET-1 is sufficient to cause increased expression of inflammatory cytokines and an inflammatory cardiomyopathy leading to heart failure and death.
|
14718401 |
2004 |