Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We assessed the role of endothelin-1, acting through endothelin A (ET<sub>A</sub> ) receptors, in modulating the central and peripheral cardiovascular responses to exercise in patients with hypertension via local antagonism of these receptors during exercise.
|
31705661 |
2020 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Opposite alterations of endothelin-1 in lung and pulmonary artery mirror gene expression of bone morphogenetic protein receptor 2 in experimental pulmonary hypertension.
|
31012341 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin 1 Is Associated with Heart Failure Hospitalization and Long-Term Mortality in Patients with Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension.
|
31514181 |
2020 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide considered to be causally implicated in hypertension and the development of cardiovascular disease.
|
31630572 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1), as it functions as a neuromodulator, has been associated with hypertension in chronic intermittent hypoxia (CIH) which attribute to enhanced carotid body sensibility to hypoxia.
|
30579678 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The most potent vasoconstrictor, endothelin-1 and its receptors, endothelin receptor A (EDNRA) and endothelin receptor B (EDNRB) are involved in hypertension.
|
31150867 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Mφ and ET-1 may play an important role in BP control and potentially have a critical role as a therapeutic target in hypertension.
|
30657897 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Our findings define novel molecular mechanism involving interplay between microparticles, the ET-1 system and endothelial cell pro-inflammatory and redox signalling, which may be important in cardiovascular toxicity and hypertension associated with VEGFi anti-cancer treatment.
|
30753341 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The angiotensin II AT<sub>1</sub> and the endothelin 1 ET<sub>A</sub> receptors play a crucial role in the pathogenesis of cardiovascular diseases like hypertension, heart failure, stroke, pulmonary hypertension, and cardiac hypertrophy.
|
30851407 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is a potential contributor to sex differences in the pathophysiology of hypertension.
|
30606254 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
This resulted in a rapid onset of hypertension, a decrease in eNOS expression, and an increase in endothelin-1 plasma levels, with all mice dying within 5 wk.
|
31196980 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1/nitric oxide balance and HOMA index in children with excess weight and hypertension: a pathophysiological model of hypertension.
|
30923371 |
2019 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results indicated that the mechanisms of hypertension in AMA may differ from those in young individuals from the point of VEGF-endothelin-1 system.
|
31272714 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Logistic regression models indicated that hypertension duration (P<0.001, 95% CI: 0.962-0.988) and ET-1 level (P<0.001, 95% CI: 1.144-1.278) were significantly associated with HRP.
|
30651821 |
2019 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In addition, RhoA expression was downregulated when oxidative stress was attenuated by DPI, while Y-27632 decreased the expression of endothelin-1, which is overexpressed in the vascular wall during hypertension.
|
30609027 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1), N-terminal fragment of pro-atrial natriuretic peptide (NTpro-ANP), and tumour necrosis factor alpha (TNF-α) in children with primary hypertension and hypertension of renal origin.
|
30359461 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In summary, in hypertension, pioglitazone shifts the vascular ET<sub>A</sub>/ET<sub>B</sub> ratio, reduces ROS/COX-2 activation and increases NO availability; these changes explain the effect of ET-1 decreasing phenylephrine-induced contraction.
|
31712626 |
2019 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These findings highlight the role of endothelin-1 in driving biventricular remodeling secondary to RV hypertension and suggest that early therapy with an endothelin-1 receptor blocker may be beneficial in attenuating biventricular remodeling but that late therapy is also effective.
|
29446710 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in order to limit ET-1-mediated action is still in progress.
|
29738719 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Magnesium attenuates endothelin-1-induced vasoreactivity and enhances vasodilatation in mouse pulmonary arteries: Modulation by chronic hypoxic pulmonary hypertension.
|
29363240 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Ambrisentan is a highly selective endothelin-1 type A receptor antagonist indicated for use in the treatment of pulmonary hypertension.
|
29289894 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph.
|
29190633 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Thus, loss of ET-1-dependent natriuresis may account for sodium retention during stress and may predispose retainers to renal diseases such as hypertension and kidney disease.
|
29246686 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The goal of this study is to elucidate the role of Endothelin-1 (ET-1) in aortic stiffening-induced hypertension through ET<sub>A</sub> receptor activation.
|
29449619 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The present study was designed to test the hypothesis that VEGF receptor inhibitor treatment leads to hypertension through decreased renal medullary formation of NO and endothelin-1.
|
29311252 |
2018 |