EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Obesity and insulin resistance are positively correlated with plasma endothelin-1 (ET-1) levels; however, the mechanisms leading to increased ET-1 are not understood. 31147283 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The urinary CRP and 8-isoprostane significantly correlated with the obesity measures (body mass index, waist circumference, and waist-to- height ratio) and ET-1, inflammatory, and oxidative markers. 31737180 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 AlteredExpression disease BEFREE Moreover, the mRNA expression of ET-1 was significantly increased in cultured HAECs in response to acute (< 24 h) and chronic (12-16 days) treatments with palmitic acid (PA), one of the most abundant saturated fatty acids in obesity. 29996135 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Five hours of prolonged sitting, relative to regular interruptions to sitting time, impaired femoral artery vasodilator function and increased circulating ET-1 in overweight/obese adults. 30188800 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Decreased ET-1 vasoconstriction is an important mechanism underlying the aerobic exercise-induced improvement in endothelium-dependent vasodilator function in overweight/obese adults. 28635124 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE These observations and the identification of endothelin-1 as soluble mediator of the cardiovascular risk factor obesity may have relevant therapeutic implications. 28705795 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The combination of HFD and TET<sup>het</sup> overexpression increased the contractions of MRA and SRA to vasoconstrictors but not in the presence of meclofenamate; this combination also augmented further relaxations to isoproterenol in the A. Contractions to endothelin-1 in the IA were prevented by endothelin-A receptor antagonist BQ-123 but only attenuated in obese mice by BQ-788. 28216625 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Patients with central obesity have impaired insulin-stimulated vasodilation and increased ET-1 (endothelin 1) vasoconstriction, which may contribute to insulin resistance and vascular damage. 28289180 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE However, during exercise, the ET-1 concentration at each step was significantly lower (p < 0.05) in the obese group. 28977804 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Transgenic expression of APPL1 prevented age- and obesity-induced impairment in insulin-induced vasodilation and reversed obesity-induced augmentation in insulin-evoked ET-1-dependent vasoconstriction. 21926268 2011
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE An increased effect of ET-1 could be a mechanism that contributes to increased basal lipolysis in human obesity. 18982011 2009
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Overweight/obese subjects (body mass index > or = 25 kg/m2) had 35% to 130% higher VECPE of NAD(P)H oxidase-p47(phox), nitrotyrosine, catalase, and the cytosolic antioxidant CuZn superoxide dismutase (all P < 0.05), as well as a 56% greater VECPE of the potent local vasoconstrictor endothelin-1 (P = 0.05) than normal-weight subjects (body mass index < 25 kg/m2). 17242275 2007
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Another variant in the EDN1 gene in linkage disequilibrium with the Lys198Asn polymorphism may be responsible for the association with BP, or the interaction between the EDN1 Lys198Asn polymorphism and other factors such as obesity may be involved in the mechanisms elevating BP in vivo. 15198485 2004
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The pathomechanisms underlying this ET-1 increase in obesity are poorly understood. 11934840 2002