Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype BEFREE The ratio between apelin and ET-1 was negatively correlated to observational baseline pain. 25486928 2015
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype BEFREE There is growing evidence that ET-1 plays a role in the pain signaling system and triggers overt nociception in humans. 24151613 2014
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype CTD_human The pain-like behavior caused by ET-1 was inhibited by phospholipase C inhibitor, but not by protein kinase C inhibitor. 20042899 2010
CUI: C0030193
Disease: Pain
Pain
0.350 AlteredExpression phenotype BEFREE The present study assessed the effects of ETBR activation and the role of endogenous opioid analgesia in carcinoma pain using an orthotopic cancer pain mouse model. mRNA expression analysis showed that ET-1 was nearly doubled while ETBR was significantly down-regulated in a human oral SCC cell line compared to normal oral keratinocytes (NOK). 20206445 2010
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype CTD_human We found that TRPA1 antagonists, HC-030031 and AP18, significantly reduced the pain-like behavior caused by ET-1. 20042899 2010
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype CTD_human Here, we investigated whether TRPA1 is involved in endothelin-1 (ET-1)-induced spontaneous pain-like behavior in C57BL/6J mice. 20042899 2010
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype CTD_human Our results suggested that TRPA1 is involved in ET-1-induced spontaneous pain-like behavior in mice. 20042899 2010
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype CTD_human Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats. 19429182 2009
CUI: C0030193
Disease: Pain
Pain
0.350 Biomarker phenotype BEFREE In this study we investigated the role of endothelin-1 (ET-1) and its peripheral receptor (ET-A) in carcinoma-induced pain in a mouse cancer pain model. 16807013 2007
CUI: C0030193
Disease: Pain
Pain
0.350 GeneticVariation phenotype BEFREE The association of endothelin 1 (ET-1) and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphisms (G5665T and T8002C, VNTR and T-786C respectively) with the occurrence of acute chest syndrome and painful vaso-occlusive crises was evaluated in homozygous SS children. 16956834 2006