EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE The following markers showed statistically significant increased mean concentrations in patients with SSc in comparison to healthy control: resistin (13.41 vs 8.54 ng/mL; P = 0.0012), endothelin-1 (1.99 vs 1.31 pg/mL; P = 0.0072) and fractalkine (2.93 vs 1.68 ng/mL; P = 0.0007). 31667578 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE Considering the role of endothelin-1 (ET-1) in tissue remodeling and fibrosis during the development of scleroderma as well as the effect of α-Klotho in pathogenesis of calcinosis and/or endothelial cell injury and its correlation with severity of disease, this study aimed to evaluate serum ET-1, α-Klotho and 25(OH) vitamin D levels in patients with limited and diffuse scleroderma compared to healthy subjects. 28831601 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE EMPs, s-Fractalkine and endothelin-1 were independent factors associated with SSc. 28320472 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE This study identified endothelium dysfunction biomarkers (FMD and ET-1) and severe microvascular damage in NVC as strong predictors of new DU in SSc patients. 28128745 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE Autoantibodies against angiotensin II type I receptor (AT1R) and endothelin-1 type A receptor (ETAR) play important roles in the pathogenesis of SSc. 26970493 2016
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE Many previous studies have focused on the role of ET-1 in scleroderma (systemic sclerosis, SSc). 25990837 2016
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE Fibroblasts isolated from healthy controls and SSc patients were treated with TGF-β and ET-1 and successively analyzed for alpha smooth muscle actin (α-SMA) and collagen (Col1A1) expression and for the Sma and Mad Related (SMAD) phosphorylation. 26357964 2015
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE Like endothelin-1 (ET-1), U-II could play an important role in SSc pathogenesis. 22045841 2012
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE In patients with systemic sclerosis (SSc), the relationship between innate immune activation, represented by increased expression of interferon (IFN)-regulated genes, and vascular injury/activation, manifest by increased endothelin-1 (ET-1), endothelin converting enzyme-1 (ECE1) and intercellular adhesion molecule-1, is uncertain. 21068089 2011
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 AlteredExpression disease LHGDN Endothelin-1 does not change the function of monocyte-derived dendritic cells grown from patients with systemic sclerosis. 18991099 2008
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 AlteredExpression disease LHGDN [Assessment of plasma endothelin level measurement in systemic sclerosis]. 17291632 2007
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE In the present study we investigated the ratio of circulating nitric oxide to endothelin-1 in patients with both SSc and PAH, and determined whether polymorphisms in NOS2 (the nitric oxide synthase 2 gene) are associated with susceptibility to PAH. 16813666 2006
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 AlteredExpression disease BEFREE This study was undertaken to delineate the signal transduction pathways utilized by ET-1 and compare them with those adopted by proinflammatory cytokine interleukin-1beta (IL-1beta) in normal and scleroderma dermal fibroblasts. 16447227 2006
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE It has been well confirmed that plasma endothelin-1, as a vasoconstrictive factor, is elevated in patients with SSc. 14632763 2003
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE Moreover, reduced responsiveness to exogenous endothelin-1 in systemic sclerosis suggests that downstream pathways may have already been activated in vivo. 11231316 2001
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 AlteredExpression disease BEFREE Microautoradiographic analysis after 125I-labeled ET-1 binding showed a two- to threefold increase in the expression of total ET-1 receptors in scleroderma lung tissue localized to the alveolar epithelium and the pulmonary interstitium which was composed of mainly fibroblastic cells with macrophages and some microvessels. 9284832 1997
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.100 Biomarker disease BEFREE The findings indicate that the overproduction of ET-1 is a novel abnormal function in SSc fibroblasts, and that ET-1 induced by fibroblasts may play a role in the fibrosis and Raynaud's phenomenon of SSc. 7944634 1994