|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
An alternative model utilizes endothelin-1 application focally to cerebral vasculature, resulting in an ischemic reperfusion injury which more closely mimics that seen in human clinical stroke.
|
31073782 |
2019 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Poly-Arginine Peptides R18 and R18D Improve Functional Outcomes After Endothelin-1-Induced Stroke in the Sprague Dawley Rat.
|
30888409 |
2019 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
However, the activation of GABAA receptors partially improved the rats' behavioral performance after the ET-1-induced stroke.
|
31227671 |
2019 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
However, it is unclear whether the observed severe brain damage in GET-1 mice post stroke is due to ET-1 dysregulation of neurogenesis by altering the stem cell niche.
|
31733648 |
2019 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Co-administration of LMT-28 with wt-tPA blocked the augmentation of JNK and ET-1 post stroke.
|
29476447 |
2019 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Disorders that increase the risk of stroke, including hypertension, diabetes mellitus, and acute myocardial infarction, are associated with increased plasma levels of ET-1.
|
31500524 |
2019 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
The use of endothelin-1 as a vasoconstrictor applied to the perivascular surface of the middle cerebral artery is one of the only methods for inducing stroke in conscious animals.
|
29468588 |
2018 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
To develop a cognitive stroke model, focal bilateral lesions were induced in the medial prefrontal cortex (mPFC) of adult mice using endothelin-1.
|
29740308 |
2018 |
|
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Tissue-type plasminogen activator -A<sup>296-299</sup> prevents impairment of cerebral autoregulation and histopathology after stroke by inhibiting upregulation of ET-1.
|
28703856 |
2018 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
The ability of endothelin-1 to stimulate brain production of H<sub>2</sub>S may counteract the reduction in cerebral blood flow and prevent the cerebral vascular dysfunction caused by stroke, asphyxia, cerebral hypoxia, ischemia, and vasospasm.
|
30265150 |
2018 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Prospective manipulation of these factors using endothelin-1-induced stroke (n = 49) was used to validate the model.
|
29334831 |
2018 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
In the current study, male Sprague Dawley rats were subjected to endothelin-1 induced stroke.
|
29778441 |
2018 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
We demonstrated an increased contractile response to endothelin 1 and extracellular potassium as well as an increased carbachol-induced dilator response in the middle cerebral arteries from hypertensive rats after stroke.
|
29190633 |
2018 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
The vasoconstrictor Endothelin-1, presenting long-term neurological deficits associated with excitotoxicity and oxidative stress is being increasingly used to induce focal ischemic injury as a model of stroke.
|
29489843 |
2018 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Because ET1 is a risk factor for ischemic stroke, our findings might also help to explain the potential mechanism of emotional abnormality in stroke.
|
28302570 |
2017 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
This data suggest that ET-1 can induce transient ischemic stroke in rhesus monkey and that ET-1 induced focal ischemia in non-human primates is a potential model to study the mechanism of stroke and brain repair after stroke.
|
28358140 |
2017 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
FR122047 (COX-1 inhibitor) was given beginning 7 days following stroke (cortical microinjection of endothelin-1) in 23 adult male rats.
|
28703413 |
2017 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
CTD_human |
SO2 inhalation contributes to the development and progression of ischemic stroke in the brain.
|
20083630 |
2010 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using data from the Stroke Prevention in Young Women study, a population-based case-control study including 297 women aged 15 to 49 years with ischemic stroke and 422 women without stroke, we evaluated whether polymorphisms in genes regulating endothelial function, including endothelin-1 (EDN), endothelin receptor type B (EDNRB), and nitric oxide synthase-3 (NOS3), confer susceptibility to migraine and stroke.
|
19661472 |
2009 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
LHGDN |
High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA.
|
18436890 |
2008 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
LHGDN |
Pathophysiology of endothelin and medical emergencies.
|
12855940 |
2003 |