EDN1, endothelin 1, 1906

N. diseases: 679; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Endothelin-1 (ET-1) and arginase are both suggested to be involved in the inflammatory processes and development of endothelial dysfunction in atherosclerosis. 31606133 2020
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 AlteredExpression phenotype BEFREE PPB or ECE attenuated endothelial dysfunction by enhancing the pAMPK-PI3K-peNOS pathway and reducing the expression of endothelin-1 (ET-1). 31731817 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Through EV mRNA profiling, 15 up-regulated and 4 down-regulated genes in patients with PA compared with EH were identified; moreover, EDN1 was expressed only in patients with PA. Microarray platform was validated by quantative real-time polymerase chain reaction on 4 genes ( CASP1, EDN1, F2R, and HMOX1) involved in apoptosis, inflammation, and endothelial dysfunction. 31230554 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE More importantly, the endothelial dysfunction regulated by ET-1 and subsequently the effect on macrophage activation were mediated by ETA receptor and largely reversed by protein kinase C (PKC) inhibitor. 31111864 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Imbalance between insulin vascular actions via the phosphatidylinositol 3-Kinase (PI3K) and the mitogen activated protein kinase (MAPK) signaling pathways during insulin resistant states results in impaired endothelial PI3K/eNOS- and augmented MAPK/endothelin 1 pathways leading to endothelial dysfunction and abnormal vasoconstriction. 30787881 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Endothelin-1, a circulating biomarker of endothelial dysfunction, was associated with both lower Dl<sub>CO</sub> and greater coronary artery calcium in those with HIV infection. 31113229 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE These mechanisms may involve ET-1 and were characterized by endothelial dysfunction and enhanced vasoconstriction. 30165438 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation, and atherosclerosis. 29654172 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 AlteredExpression phenotype BEFREE We examined the ability of metformin + esomeprazole to rescue TNF-α induced vascular cell adhesion molecule-1 (VCAM-1) and Endothelin-1 (ET-1) expression, leukocyte adhesion (markers of endothelial dysfunction). 29466360 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE The present study demonstrated that the reduction of NO bioavailability and release results from elevated Arg-2, accumulation of intracellular ADMA, and imbalance of ET-1 and ET<sub>B</sub>R, further leading to IUGR-associated vascular endothelial dysfunction. 30392707 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE In addition, quercetin reduced the pancreatic ER stress-induced endothelial dysfunction as assessed by immunohistochemical analysis of C/ERB homologous protein (CHOP) and endothelin-1 (ET-1). 29169872 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Endothelin-1 (ET-1) is associated with endothelial dysfunction and vasoconstriction. 29743680 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 AlteredExpression phenotype BEFREE Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet pattern, exercise and atorvastatin modulate the expression of eNOS, inducible NOS (iNOS), endothelin-1, sirtuins (SIRT) and microRNA-155 in the erectile tissue of high-fat fed aged rats. 29686722 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE This resulted into two articles: in the first, we herein examine the mechanisms by which endothelial factors induce vascular remodeling and the role of different players, including endothelin-1, the renin-angiotensin-aldosterone system and their interactions, and of oxidative stress; in the second, we discuss the role of endothelial dysfunction in the major disease conditions that affect the kidney. 29120962 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 AlteredExpression phenotype BEFREE Thus, we aimed to investigate the effect of TMST on endothelial dysfunction in CSFP, Endothelial-dependent flow-mediated vasodilation, serum levels of nitric oxide, adiponectin, and endothelin-1 were surveyed before and after 3 months of TMST treatment. 29314204 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Considering the importance of serum soluble vascular cell adhesion molecule-1 as the most abundant of the circulating adhesion molecules increased as a result of endothelial dysfunction and the role of endothelin-1 in pathophysiology of SLE, this study aimed to evaluate serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels in SLE patients compared to healthy subjects. 30157717 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 AlteredExpression phenotype BEFREE Over activation of the endothelin-1 (ET-1) system in disease states contributes to endothelial dysfunction. 29947542 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE The objectives of this study were: a) to determine the relative contribution of cyclooxygenases (Cox-1 and Cox-2), thromboxane A2 (TXA2) and endothelin-1 (ET-1) to enhancing vascular hyperresponsiveness in this model of atherosclerosis and b) to investigate the beneficial effects of the phosphodiesterase 5 inhibitor sildenafil on this endothelial dysfunction. 29216624 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE In this study, we aimed to determine the relation of adropin with biochemical and radiologic parameters which reflect ED such as endothelial nitric oxide synthase (eNOS), endothelin 1 (ET-1), nitric oxide (NO) and flow-mediated dilatation (FMD) along with the routine biochemical measurements in patients recently diagnosed with metabolic syndrome (MetS). 27474839 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. 26450601 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Aorta incubated with AS exhibited a reversal in ET-1 induced vascular and endothelial dysfunction. 28830679 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Endothelin-1, a marker of endothelial dysfunction, is a potent vasoconstrictor released by endothelial cells and an important regulator of renal physiology. 28698270 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 Biomarker phenotype BEFREE Endothelin-1 (ET-1) contributes to age-related endothelial dysfunction in men via the ET<sub>A</sub> receptor. 28438762 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 AlteredExpression phenotype BEFREE Optimism and gratitude were associated with lower levels of markers of endothelial dysfunction (endothelin-1: gratitude: β = -.009; 95% [CI] = -.017 to - .001]; optimism: β = -.009; 95% [CI] = -.016 to - .001]; soluble intercellular adhesion molecule-1: gratitude: β = -.007; 95% [CI] = -.014 to - .000]), independent of depressive and anxiety symptoms. 27749683 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction
0.100 AlteredExpression phenotype BEFREE During exposure to ischemia-reperfusion (I/R) insult, angiotensin II (AngII)-induced endothelin-1 (ET-1) upregulation in endothelial cells progressively impairs nitric oxide (NO) bioavailability while increasing levels of superoxide anion (O<sub>2</sub><sup>-</sup>) and leading to the onset of endothelial dysfunction. 28715643 2017