Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Endothelin-1 (ET-1) and arginase are both suggested to be involved in the inflammatory processes and development of endothelial dysfunction in atherosclerosis.
|
31606133 |
2020 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
PPB or ECE attenuated endothelial dysfunction by enhancing the pAMPK-PI3K-peNOS pathway and reducing the expression of endothelin-1 (ET-1).
|
31731817 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Through EV mRNA profiling, 15 up-regulated and 4 down-regulated genes in patients with PA compared with EH were identified; moreover, EDN1 was expressed only in patients with PA. Microarray platform was validated by quantative real-time polymerase chain reaction on 4 genes ( CASP1, EDN1, F2R, and HMOX1) involved in apoptosis, inflammation, and endothelial dysfunction.
|
31230554 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
More importantly, the endothelial dysfunction regulated by ET-1 and subsequently the effect on macrophage activation were mediated by ETA receptor and largely reversed by protein kinase C (PKC) inhibitor.
|
31111864 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Imbalance between insulin vascular actions via the phosphatidylinositol 3-Kinase (PI3K) and the mitogen activated protein kinase (MAPK) signaling pathways during insulin resistant states results in impaired endothelial PI3K/eNOS- and augmented MAPK/endothelin 1 pathways leading to endothelial dysfunction and abnormal vasoconstriction.
|
30787881 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Endothelin-1, a circulating biomarker of endothelial dysfunction, was associated with both lower Dl<sub>CO</sub> and greater coronary artery calcium in those with HIV infection.
|
31113229 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These mechanisms may involve ET-1 and were characterized by endothelial dysfunction and enhanced vasoconstriction.
|
30165438 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Endothelin-1 (ET-1) plays important roles in endothelial dysfunction, vascular physiology, inflammation, and atherosclerosis.
|
29654172 |
2018 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We examined the ability of metformin + esomeprazole to rescue TNF-α induced vascular cell adhesion molecule-1 (VCAM-1) and Endothelin-1 (ET-1) expression, leukocyte adhesion (markers of endothelial dysfunction).
|
29466360 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The present study demonstrated that the reduction of NO bioavailability and release results from elevated Arg-2, accumulation of intracellular ADMA, and imbalance of ET-1 and ET<sub>B</sub>R, further leading to IUGR-associated vascular endothelial dysfunction.
|
30392707 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In addition, quercetin reduced the pancreatic ER stress-induced endothelial dysfunction as assessed by immunohistochemical analysis of C/ERB homologous protein (CHOP) and endothelin-1 (ET-1).
|
29169872 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Endothelin-1 (ET-1) is associated with endothelial dysfunction and vasoconstriction.
|
29743680 |
2018 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet pattern, exercise and atorvastatin modulate the expression of eNOS, inducible NOS (iNOS), endothelin-1, sirtuins (SIRT) and microRNA-155 in the erectile tissue of high-fat fed aged rats.
|
29686722 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This resulted into two articles: in the first, we herein examine the mechanisms by which endothelial factors induce vascular remodeling and the role of different players, including endothelin-1, the renin-angiotensin-aldosterone system and their interactions, and of oxidative stress; in the second, we discuss the role of endothelial dysfunction in the major disease conditions that affect the kidney.
|
29120962 |
2018 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, we aimed to investigate the effect of TMST on endothelial dysfunction in CSFP, Endothelial-dependent flow-mediated vasodilation, serum levels of nitric oxide, adiponectin, and endothelin-1 were surveyed before and after 3 months of TMST treatment.
|
29314204 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Considering the importance of serum soluble vascular cell adhesion molecule-1 as the most abundant of the circulating adhesion molecules increased as a result of endothelial dysfunction and the role of endothelin-1 in pathophysiology of SLE, this study aimed to evaluate serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels in SLE patients compared to healthy subjects.
|
30157717 |
2018 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Over activation of the endothelin-1 (ET-1) system in disease states contributes to endothelial dysfunction.
|
29947542 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The objectives of this study were: a) to determine the relative contribution of cyclooxygenases (Cox-1 and Cox-2), thromboxane A2 (TXA2) and endothelin-1 (ET-1) to enhancing vascular hyperresponsiveness in this model of atherosclerosis and b) to investigate the beneficial effects of the phosphodiesterase 5 inhibitor sildenafil on this endothelial dysfunction.
|
29216624 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this study, we aimed to determine the relation of adropin with biochemical and radiologic parameters which reflect ED such as endothelial nitric oxide synthase (eNOS), endothelin 1 (ET-1), nitric oxide (NO) and flow-mediated dilatation (FMD) along with the routine biochemical measurements in patients recently diagnosed with metabolic syndrome (MetS).
|
27474839 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension.
|
26450601 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Aorta incubated with AS exhibited a reversal in ET-1 induced vascular and endothelial dysfunction.
|
28830679 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Endothelin-1, a marker of endothelial dysfunction, is a potent vasoconstrictor released by endothelial cells and an important regulator of renal physiology.
|
28698270 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Endothelin-1 (ET-1) contributes to age-related endothelial dysfunction in men via the ET<sub>A</sub> receptor.
|
28438762 |
2017 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Optimism and gratitude were associated with lower levels of markers of endothelial dysfunction (endothelin-1: gratitude: β = -.009; 95% [CI] = -.017 to - .001]; optimism: β = -.009; 95% [CI] = -.016 to - .001]; soluble intercellular adhesion molecule-1: gratitude: β = -.007; 95% [CI] = -.014 to - .000]), independent of depressive and anxiety symptoms.
|
27749683 |
2017 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
During exposure to ischemia-reperfusion (I/R) insult, angiotensin II (AngII)-induced endothelin-1 (ET-1) upregulation in endothelial cells progressively impairs nitric oxide (NO) bioavailability while increasing levels of superoxide anion (O<sub>2</sub><sup>-</sup>) and leading to the onset of endothelial dysfunction.
|
28715643 |
2017 |